1. Gene
  2. Prkcg - protein kinase C, gamma Gene

Prkcg - protein kinase C, gamma Gene

中文名称:蛋白激酶 C, γ

种属: Rattus norvegicus

同用名: PKC; PKCI; Prkc; Prkcc; RATPKCI

基因 ID: 24681 | 基因类型: protein coding

关于 Prkcg

Primary_assembly 1: 65,832,855-65,859,384 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 201 orthologues, 9 paralogues and is associated with 15 phenotypes. Biased expression in Brain (RPKM 143.9), Spleen (RPKM 12.) and 2 other tissues.

功能概要

该基因编码的蛋白可启动钙依赖性蛋白激酶 C 活性。涉及多个过程,包括长期突触增强;蛋白质自身磷酸化;和对社会心理压力的反应。位于多个细胞成分中,包括树突;细胞质的核周区;和突触膜。在突触后细胞质中活跃。该基因的人类直系同源基因与 14 型脊髓小脑性共济失调有关。与人类 PRKCG(蛋白激酶 C 伽玛)直系同源基因。 [由基因组资源联盟提供,2022 年 4 月]

Enables calcium-dependent protein kinase C activity. Involved in several processes, including long-term synaptic potentiation; protein autophosphorylation; and response to psychosocial stress. Located in several cellular components, including dendrite; perinuclear region of cytoplasm; and synaptic membrane. Is active in postsynaptic cytosol. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 14. Orthologous to human PRKCG (protein kinase C gamma). [provided by Alliance of Genome Resources, Apr 2022]

Prkcg 基因产物(2)

mRNA Protein Name
NM_012628.2 NP_036760.1 protein kinase C gamma type
NM_012628.2 NP_036760.1 protein kinase C gamma type
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18972403 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8940095 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in learning or memory IEP
IEP: 通过表达模式推断
12000125 RGD
involved in long-term synaptic potentiation IDA
IDA: 通过直接分析推断
10501452 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
15705736 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
18972403 RGD
involved in response to angiotensin IDA
IDA: 通过直接分析推断
11507002 RGD
involved in response to psychosocial stress IDA
IDA: 通过直接分析推断
9287082 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
12560106 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
11507002 RGD
located in dendrite IDA
IDA: 通过直接分析推断
12471040 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
12471040 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
12471040 RGD
is active in postsynaptic cytosol IDA
IDA: 通过直接分析推断
2202488 RGD
located in synaptic membrane IDA
IDA: 通过直接分析推断
12560106 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Prkcg 蛋白结构

C1_cPKC_rpt1

C1_cPKC_rpt1: cd20833 (33 - 90)

C1_cPKC_rpt2

C1_cPKC_rpt2: cd20836 (100 - 153)

C2_PKC_alpha_gamma

C2_PKC_alpha_gamma: cd04026 (157 - 288)

STKc_cPKC

STKc_cPKC: cd05587 (353 - 676)

  • 0
  • 200
  • 400
  • 600
  • 697 a.a.
蛋白主名 其他名称

protein kinase C gamma type

PKC-gamma

protein kinase C type I (gamma type)

Prkcg 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Prkcg P63319 LIMK1 Homo sapiens P53667
Anti Tag CoIP
8940095
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkcg NCBI NCBI:5582