2. Gene
  3. PRKCG - protein kinase C gamma Gene

PRKCG - protein kinase C gamma Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 Cγ

种属: Homo sapiens

同用名: PKCC; PKCG; SCA14; PKCI(3); PKCgamma; PKC-gamma

基因 ID: 5582 | 基因类型: protein coding

关于 PRKCG

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:53,881,094-53,907,652 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues, 9 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 15.6) and testis (RPKM 1.4).

功能概要

蛋白激酶 C (PKC) 是一个丝氨酸和苏氨酸特异性蛋白激酶家族，可被钙和第二信使甘油二酯激活。 PKC 家族成员磷酸化多种蛋白质靶标，并且已知参与多种细胞信号通路。 PKC 还充当一类肿瘤促进剂佛波酯的主要受体。 PKC 家族的每个成员都有特定的表达谱，并被认为在细胞中发挥着不同的作用。该基因编码的蛋白质是 PKC 家族成员之一。这种蛋白激酶仅在大脑和脊髓中表达，并且其定位仅限于神经元。已经证明，几种神经元功能，包括长时程增强 (LTP) 和长时程抑制 (LTD) ，特别需要这种激酶。小鼠基因敲除研究还表明，这种激酶可能参与神经性疼痛的发展。这种蛋白质的缺陷与神经退行性疾病脊髓小脑共济失调 14 (SCA14) 有关。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2015 年 10 月]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

PRKCG 基因产物(3)

mRNA Protein Name
XM_047439092.1 XP_047295048.1 protein kinase C gamma type isoform X1
NM_002739.5 NP_002730.1 protein kinase C gamma type isoform 2
NM_001316329.2 NP_001303258.1 protein kinase C gamma type isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22939624 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
15808853 GOA
enables protein serine/threonine/tyrosine kinase activity IDA
IDA: 通过直接分析推断
22797923 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of protein catabolic process IDA
IDA: 通过直接分析推断
15808853 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
15808853 GOA
involved in phosphorylation IDA
IDA: 通过直接分析推断
15808853 GOA
involved in positive regulation of mismatch repair IDA
IDA: 通过直接分析推断
15808853 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKCG 蛋白结构

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (36 - 86)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (101 - 152)

C2

C2: C2 domain (174 - 258)

Pkinase

Pkinase: Protein kinase domain (353 - 599)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (641 - 678)

  • 0
  • 200
  • 400
  • 600
  • 697 a.a.
蛋白主名 其他名称

protein kinase C gamma type

PRKCG 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PRKCG P05129 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
31980649
Intra PRKCG P05129 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra PRKCG P05129 PIAS1 Homo sapiens O75925
Y2H Array
32814053
Intra PRKCG P05129 PIAS1 Homo sapiens O75925
Y2H Pooling
32814053
Intra PRKCG P05129 PIAS1 Homo sapiens O75925
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 13

Spinocerebellar Ataxia Type 13

SCA13

Autosomal Dominant Cerebellar Ataxia With Mental Retardation

Cerebellar Ataxia, Autosomal Dominant With Mental Retardation

Spinocerebellar Ataxia-13

Ataxia, Spinocerebellar, Type 13
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Cerebellar Ataxia Type 43

Sca43
Cerebellar Ataxia Type 42

Sca42
Retinitis Pigmentosa 62

RP62

Retinitis Pigmentosa, Type 62
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Spinocerebellar Ataxia 6

Spinocerebellar Ataxia Type 6

SCA6

Type 6 Spinocerebellar Ataxia

Spinocerebellar Ataxia-6

Ataxia, Spinocerebellar, Type 6
Hereditary Ataxia

Sca

Spinocerebellar Ataxia

Ataxias Hereditary

Ataxias, Hereditary
Spinocerebellar Ataxia, Autosomal Recessive 17

Autosomal Recessive Spinocerebellar Ataxia 17

SCAR17

Autosomal Recessive Cerebellar Ataxia Due To Cwf19l1 Deficiency

Spinocerebellar Ataxia Autosomal Recessive Type 17

Spinocerebellar Ataxia, Autosomal Recessive, 17

Ataxia, Spinocerebellar, Autosomal Recessive, Type 17
Spastic Ataxia

Spax

Ataxia, Spastic
Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1
Cerebellar Ataxia Type 48

Sca48
Aceruloplasminemia

Cerebellar Ataxia

Hypoceruloplasminemia

Hemosiderosis, Systemic, Due To Aceruloplasminemia

Familial Apoceruloplasmin Deficiency

Hereditary Ceruloplasmin Deficiency

Deficiency Of Ferroxidase

Hypoceruloplasminemia, Hereditary

Ceruloplasmin Deficiency

Systemic Hemosiderosis Due To Aceruloplasminemia

ACERULOP
Episodic Ataxia

Isaacs Syndrome

Neuromyotonia

Isaacs' Syndrome

Acquired Neuromyotonia

Continuous Muscle Fiber Activity Syndrome

Quantal Squander Syndrome

Isaacs-Mertens Syndrome

Ea Syndrome

Episodic Ataxia Syndrome

Isaac Syndrome

Isaac'S-Merten'S Syndrome

Isaac-Mertens Syndrome

Peripheral Nerve Hyperexcitability

Ea

Ataxia, Episodic

Isaacs Neuromyotonia

Continuous Muscle Fibre Activity
Cerebellar Disease

Cerebellar Diseases

Cerebellar Dysfunction

Cerebellar Abnormality

Cerebellar Disorders
Episodic Ataxia, Type 2

Episodic Ataxia Type 2

EA2

Apca

Capa

Cerebellopathy, Hereditary Paroxysmal

Acetazolamide-Responsive Hereditary Paroxysmal Cerebellar Ataxia

Cerebellar Ataxia, Paroxysmal, Acetazolamide-Responsive

Episodic Ataxia With Nystagmus

Ataxia, Episodic, With Nystagmus

Episodic Ataxia, Nystagmus-Associated

Ataxia, Familial Paroxysmal

Acetazolamide-Responsive Episodic Ataxia Syndrome

Acetazolamide-Responsive, Hereditary, Paroxysmal, Cerebellar Ataxia

Ataxia, Familial, Paroxysmal

Nystagmus-Associated Episodic Ataxia

Familial Paroxysmal Ataxia

Episodic Ataxia 2

Ea-2

Episodic Ataxia Nystagmus-Associated

Hereditary Paroxysmal Cerebellopathy

Ataxia, Episodic, Type 2
Dentatorubral-Pallidoluysian Atrophy

DRPLA

Naito-Oyanagi Disease

Haw River Syndrome

Myoclonic Epilepsy With Choreoathetosis

Nod

Ataxia, Chorea, Seizures, And Dementia

Dentatorubropallidoluysian Atrophy

Hrs

Naito Oyanagi Disease

Dentatorubral Pallidoluysian Atrophy

Dentatorubro-Pallidoluysian Atrophy

Myoclonic Epilepsies, Progressive

Atrophy, Pallidoluysian, Dentatorubral
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Cerebellar Ataxia Type 41

Sca41
Spinocerebellar Ataxia 14

Spinocerebellar Ataxia Type 14

SCA14

Ataxia, Spinocerebellar, Type 14
Friedreich Ataxia

Friedreich Ataxia 1

FRDA

Friedreich Ataxia With Retained Reflexes

Frda1

Fa

Friedreich'S Ataxia

Hereditary Spinal Ataxia

Fa1

Friedreich'S Tabes

Hereditary Spinal Sclerosis

Spinocerebellar Ataxia, Friedreich

Friedreich Spinocerebellar Ataxia

Friedrich'S Ataxia
Spinocerebellar Ataxia 15

SCA15

Spinocerebellar Ataxia Type 15

Spinocerebellar Ataxia Type 16

Sca16

Spinocerebellar Ataxia Type 15/16

Spinocerebellar Ataxia 16, Formerly

Sca16, Formerly

Spinocerebellar Ataxia 16

Sca15/16

Ataxia, Spinocerebellar, Type 15
Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder

CHDFIDD

Cdk13-Related Chdfidd

Cdk13-Related Disorder

Cdk13-Related Congenital Heart Defects, Dysmorphic Facial Features, Intellectual Developmental Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11128 PRKCG Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11129 Prkcg Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11130 Prkcg Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PRKCG VGNC VGNC:33331
Macaca mulatta PRKCG VGNC VGNC:76413
Rattus norvegicus PRKCG RGD RGD:3397
Mus musculus PRKCG MGD MGI:97597
Felis catus PRKCG VGNC VGNC:69061
Others PRKCG NCBI
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