2. Gene
  3. ALOX15B - arachidonate 15-lipoxygenase type B Gene

ALOX15B - arachidonate 15-lipoxygenase type B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：花生四烯酸 15-脂氧合酶 B 型

种属: Homo sapiens

同用名: 15-LOX-2

基因 ID: 247 | 基因类型: protein coding

关于 ALOX15B

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,039,059-8,049,134 (from NCBI)

This gene has 5 transcripts (splice variants), 218 orthologues and 5 paralogues. Biased expression in prostate (RPKM 42.3), esophagus (RPKM 13.5) and 2 other tissues.

功能概要

该基因编码脂肪氧化酶家族的成员，该家族属于结构相关的非血红素铁双加氧酶，参与脂肪酸氢过氧化物的产生。编码的蛋白质将花生四烯酸专门转化为 15S-氢过氧二十碳四烯酸，而代谢亚油酸的效率较低。该基因位于 17 号染色体短臂上的一组相关基因和一个跨越大约 100 千碱基的假基因中。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ALOX15B 基因产物(3)

mRNA Protein Name
NM_001039130.2 NP_001034219.1 polyunsaturated fatty acid lipoxygenase ALOX15B isoform a
NM_001039131.2 NP_001034220.1 polyunsaturated fatty acid lipoxygenase ALOX15B isoform b
NM_001141.3 NP_001132.2 polyunsaturated fatty acid lipoxygenase ALOX15B isoform d

ALOX15B 蛋白结构

PLAT

PLAT: PLAT/LH2 domain (5 - 118)

Lipoxygenase

Lipoxygenase: Lipoxygenase (214 - 667)

  • 0
  • 200
  • 400
  • 600
  • 676 a.a.
蛋白主名 其他名称

polyunsaturated fatty acid lipoxygenase ALOX15B

15-LOX-B

重组 ALOX15B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74436 15 Lipoxygenase 2 Protein, Human (sf9, His-GST) O15296 (M1-I676) ≥95%
HY-P74437 15 Lipoxygenase 2 Protein, Human (sf9) O15296 (N-G&P, M1-I676) ≥95%

关联疾病

疾病名称 别名
Ectopia Lentis Et Pupillae

Ectopia Lentis With Ectopia Of Pupil

ECTOLP
Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Ichthyosis, Congenital, Autosomal Recessive 3

Autosomal Recessive Congenital Ichthyosis 3

ARCI3

Lamellar Ichthyosis 5

Collodion Baby, Self-Healing

Ichthyosis, Lamellar, 5, Formerly

Li5, Formerly

Li5

Self-Healing Collodion Baby

Ichthyosis, Congenital, Autosomal Recessive, Type 3
Primary Cutaneous Amyloidosis

Plca

Primary Localized Cutaneous Amyloidosis

Familial Primary Localized Cutaneous Amyloidosis

Amyloidosis Ix

Lichen Amyloidosis Familial

Amyloidosis, Primary Cutaneous

Pca

Amyloidosis 9

Amyloidosis Familial Cutaneous Lichen

Fplca

Familial Lichen Amyloidosis
Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00619 ALOX15B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ALOX15B VGNC VGNC:59756
Macaca mulatta ALOX15B VGNC VGNC:69797
Canis familiaris ALOX15B VGNC VGNC:37812
Rattus norvegicus ALOX15B RGD RGD:628809
Mus musculus ALOX15B MGD MGI:1098228
Bos taurus ALOX15B VGNC VGNC:55769
Others ALOX15B NCBI
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