2. Gene
  3. Tacr1 - tachykinin receptor 1 Gene

Tacr1 - tachykinin receptor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：速激肽受体 1

种属: Rattus norvegicus

同用名: Tac1r

基因 ID: 24807 | 基因类型: protein coding

关于 Tacr1

Primary_assembly 4: 114,920,844-115,089,733 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 270 orthologues, 50 paralogues and is associated with 34 phenotypes. Biased expression in Spleen (RPKM 7.7), Brain (RPKM 7.5) and 8 other tissues.

功能概要

该基因编码的蛋白可启动 P 物质受体活性。涉及多个过程，包括学习或记忆；分泌的正调节；和细胞迁移的调节。位于多个细胞成分中，包括细胞体；细胞表面；和树突。用于研究中枢性睡眠呼吸暂停；膀胱炎;胰腺炎;和肺动脉高压。急性坏死性胰腺炎的生物标志物；过敏性鼻炎;哮喘;结肠炎;和呼吸道合胞病毒感染性疾病。该基因的人类直系同源物与运动引起的支气管收缩有关。与人 TACR1（速激肽受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables substance P receptor activity. Involved in several processes, including learning or memory; positive regulation of secretion; and regulation of cell migration. Located in several cellular components, including cell body; cell surface; and dendrite. Used to study central sleep apnea; cystitis; pancreatitis; and pulmonary hypertension. Biomarker of acute necrotizing pancreatitis; allergic rhinitis; asthma; colitis; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in exercise-induced bronchoconstriction. Orthologous to human TACR1 (tachykinin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tacr1 基因产物(1)

mRNA Protein Name
NM_012667.3 NP_036799.1 substance-P receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables substance P receptor activity IDA
IDA: 通过直接分析推断
7683643 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aggressive behavior IMP
IMP: 通过突变表型推断
17678879 RGD
involved in angiotensin-mediated drinking behavior IMP
IMP: 通过突变表型推断
9437747 RGD
involved in associative learning IMP
IMP: 通过突变表型推断
19071162 RGD
involved in behavioral response to pain IMP
IMP: 通过突变表型推断
18407414 RGD
involved in eating behavior IMP
IMP: 通过突变表型推断
17141213 RGD
involved in learning or memory IMP
IMP: 通过突变表型推断
21611833 RGD
involved in long-term memory IMP
IMP: 通过突变表型推断
19071162 RGD
involved in operant conditioning IMP
IMP: 通过突变表型推断
17324063 RGD
involved in positive regulation of action potential IMP
IMP: 通过突变表型推断
18440151 RGD
involved in positive regulation of blood pressure IMP
IMP: 通过突变表型推断
18337316 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
17435548 RGD
involved in positive regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
17435548 RGD
involved in positive regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
18390473 RGD
involved in positive regulation of hormone secretion IMP
IMP: 通过突变表型推断
15613740 RGD
involved in positive regulation of leukocyte migration IMP
IMP: 通过突变表型推断
11803123 RGD
involved in positive regulation of lymphocyte proliferation IMP
IMP: 通过突变表型推断
18621988 RGD
involved in positive regulation of ossification IMP
IMP: 通过突变表型推断
17204323 RGD
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
17435548 RGD
involved in positive regulation of synaptic transmission, GABAergic IMP
IMP: 通过突变表型推断
19261870 RGD
involved in positive regulation of synaptic transmission, cholinergic IMP
IMP: 通过突变表型推断
17949415 RGD
involved in positive regulation of uterine smooth muscle contraction IDA
IDA: 通过直接分析推断
12390879 RGD
involved in positive regulation of vascular permeability IMP
IMP: 通过突变表型推断
18326823 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
18602450 RGD
involved in regulation of blood pressure IMP
IMP: 通过突变表型推断
18938661 RGD
involved in regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
21777465 RGD
involved in regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
21777465 RGD
involved in response to auditory stimulus IDA
IDA: 通过直接分析推断
18178320 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
18440496 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
10342838 RGD
involved in response to ethanol IMP
IMP: 通过突变表型推断
18555214 RGD
involved in response to hormone IMP
IMP: 通过突变表型推断
18195491 RGD
involved in response to nicotine IMP
IMP: 通过突变表型推断
18037142 RGD
involved in response to organic cyclic compound IDA
IDA: 通过直接分析推断
18178320 RGD
involved in response to ozone IMP
IMP: 通过突变表型推断
18390473 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
10342838 RGD
involved in smooth muscle contraction involved in micturition IMP
IMP: 通过突变表型推断
18945947 RGD
involved in sperm ejaculation IMP
IMP: 通过突变表型推断
19170843 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell body IDA
IDA: 通过直接分析推断
21611833 RGD
located in cell surface IDA
IDA: 通过直接分析推断
19261870 RGD
located in dendrite IDA
IDA: 通过直接分析推断
18178320 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
7508118 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tacr1 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (32 - 315)

7tm_GPCRs

7tm_GPCRs: cd14964 (34 - 58)

7tm_GPCRs

7tm_GPCRs: cd14964 (67 - 89)

7tm_GPCRs

7tm_GPCRs: cd14964 (105 - 127)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (193 - 216)

7tm_GPCRs

7tm_GPCRs: cd14964 (246 - 268)

7tm_GPCRs

7tm_GPCRs: cd14964 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
蛋白主名 其他名称

substance-P receptor

NK-1 receptor

NK-1R

SPR

neurokinin 1 receptor

substance p receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14143 TACR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14144 Tacr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14145 Tacr1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tacr1 NCBI NCBI:6869
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