1. Gene
  2. Tacr1 - tachykinin receptor 1 Gene

Tacr1 - tachykinin receptor 1 Gene

中文名称:速激肽受体 1

种属: Rattus norvegicus

同用名: Tac1r

基因 ID: 24807 | 基因类型: protein coding

关于 Tacr1

Primary_assembly 4: 114,920,844-115,089,733 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 270 orthologues, 50 paralogues and is associated with 34 phenotypes. Biased expression in Spleen (RPKM 7.7), Brain (RPKM 7.5) and 8 other tissues.

功能概要

该基因编码的蛋白可启动 P 物质受体活性。涉及多个过程,包括学习或记忆;分泌的正调节;和细胞迁移的调节。位于多个细胞成分中,包括细胞体;细胞表面;和树突。用于研究中枢性睡眠呼吸暂停;膀胱炎;胰腺炎;和肺动脉高压。急性坏死性胰腺炎的生物标志物;过敏性鼻炎;哮喘;结肠炎;和呼吸道合胞病毒感染性疾病。该基因的人类直系同源物与运动引起的支气管收缩有关。与人 TACR1(速激肽受体 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables substance P receptor activity. Involved in several processes, including learning or memory; positive regulation of secretion; and regulation of cell migration. Located in several cellular components, including cell body; cell surface; and dendrite. Used to study central sleep apnea; cystitis; pancreatitis; and pulmonary hypertension. Biomarker of acute necrotizing pancreatitis; allergic rhinitis; asthma; colitis; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in exercise-induced bronchoconstriction. Orthologous to human TACR1 (tachykinin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tacr1 基因产物(1)

mRNA Protein Name
NM_012667.3 NP_036799.1 substance-P receptor

Tacr1 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (32 - 315)

7tm_GPCRs

7tm_GPCRs: cd14964 (34 - 58)

7tm_GPCRs

7tm_GPCRs: cd14964 (67 - 89)

7tm_GPCRs

7tm_GPCRs: cd14964 (105 - 127)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (193 - 216)

7tm_GPCRs

7tm_GPCRs: cd14964 (246 - 268)

7tm_GPCRs

7tm_GPCRs: cd14964 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
蛋白主名 其他名称

substance-P receptor

NK-1 receptor

NK-1R

SPR

neurokinin 1 receptor

substance p receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tacr1 NCBI NCBI:6869