1. Gene
  2. TACR1 - tachykinin receptor 1 Gene

TACR1 - tachykinin receptor 1 Gene

中文名称:速激肽受体 1

种属: Homo sapiens

同用名: SPR; NK1R; NKIR; TAC1R

基因 ID: 6869 | 基因类型: protein coding

关于 TACR1

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:75,046,463-75,199,520 (from NCBI)

This gene has 3 transcripts (splice variants), 270 orthologues and 33 paralogues. Broad expression in skin (RPKM 1.8), endometrium (RPKM 1.4) and 17 other tissues.

功能概要

该基因属于速激肽受体基因家族。这些速激肽受体的特点是与 G 蛋白相互作用,并包含七个疏水性跨膜区域。该基因编码速激肽 P 物质的受体,也称为神经激肽 1。编码的蛋白质还参与 P 物质磷脂酰肌醇代谢的介导。[RefSeq 提供,2008 年 9 月]

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

TACR1 基因产物(2)

mRNA Protein Name
NM_015727.3 NP_056542.1 substance-P receptor isoform short
NM_001058.4 NP_001049.1 substance-P receptor isoform long
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12716968 GOA
enables substance P receptor activity IMP
IMP: 通过突变表型推断
12716968 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
12716968 GOA
involved in positive regulation of flagellated sperm motility IMP
IMP: 通过突变表型推断
17437961 GOA
involved in tachykinin receptor signaling pathway IDA
IDA: 通过直接分析推断
17986524 GOA
involved in tachykinin receptor signaling pathway IMP
IMP: 通过突变表型推断
12716968 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
17986524 GOA
located in sperm flagellum IDA
IDA: 通过直接分析推断
17437961 GOA
located in sperm head IDA
IDA: 通过直接分析推断
17437961 GOA
located in sperm midpiece IDA
IDA: 通过直接分析推断
17437961 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TACR1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (49 - 305)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
蛋白主名 其他名称

substance-P receptor

NK-1 receptor

NK-1R

neurokinin receptor 1

tachykinin receptor 1 (substance P receptor

neurokinin-1 receptor)

TACR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TACR1 P25103 TMEM147 Homo sapiens Q9BVK8 32296183
种属内
TACR1 P25103 P20366-PRO_0000033530 Homo sapiens P20366-PRO_0000033530
SPA
23597562
种属内
TACR1 P25103 CCDC167 Homo sapiens Q9P0B6 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

TACR1 抗体

目录号 产品名 应用 反应物种
HY-P81073 NK1R Antibody WB, ELISA, IHC-P, IHC-F, FC, ICC/IF Human, Rat, Guinea Pig

关联疾病

疾病名称 别名
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Complex Regional Pain Syndrome

Complex Regional Pain Syndromes

Reflex Sympathetic Dystrophy

Crps

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Psoriasis
Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder

Sleeping Sickness

African Trypanosomiasis

African Sleeping Sickness

Trypanosomiasis, Human East-African

Trypanosomiasis, East African

Trypanosomiasis African

Trypanosomiasis, African

Human African Trypanosomiasis

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Acute Necrotizing Pancreatitis

Acute Pancreatitis

Pancreatitis, Acute Necrotizing

Pancreatitis Necrotizing

Necrotizing Pancreatitis

Pancreatitis

Pancreatitis Nos

Acute Pancreas Inflammation

Autonomic Nervous System Disease

Autonomic Nervous System Dysfunction

Autonomic Nervous System Disorders

Autonomic Nervous System Disorder

Autonomic Nervous System Diseases

Abnormality Of The Autonomic Nervous System

Retinitis Pigmentosa 73

RP73

Retinitis Pigmentosa, Type 73

Central Sleep Apnea

Central Sleep Apnea Syndrome

Sleep Apnea, Central

Primary Central Sleep Apnea

Central Sleep Apnea, Primary

Central Sleep Apnoea Syndrome

Csa - [Central Sleep Apnoea]

Csas - [Central Sleep Apnoea Syndrome]

Central Sleep Apnoea Due To Substances Including Medications

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Colitis
Hepatoblastoma
Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Fibromyalgia

Diffuse Myofascial Pain Syndrome

Fibromyalgia Syndrome

Fibromyalgia-Fibromyositis Syndrome

Fibromyositis

Fibrositis

Fms

Myofascial Pain Syndrome

Myofascial Pain Syndromes

Congenital Central Hypoventilation Syndrome

Cchs

Haddad Syndrome

Ondine Curse

Ondine Syndrome

Congenital Central Hypoventilation

Congenital Central Alveolar Hypoventilation Syndrome

Congenital Failure Of Autonomic Control

Ondine'S Curse

Primary Alveolar Hypoventilation

Ondine-Hirschsprung Disease

Central Congenital Hypoventilation Syndrome

Congenital Ondine Curse

Idiopathic Congenital Central Alveolar Hypoventilation

Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome

Ondine-Hirschsprung Syndrome

Trypanosomiasis
Cystitis

Infective Cystitis

Urocystitis

Pyocystitis

Irritable Bowel Syndrome

Irritable Colon

Psychogenic Ibs

Ibs - [Irritable Bowel Syndrome]

Spastic Bowel Syndrome

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Streptococcal Meningitis
Allergic Disease

Hypersensitivity

Allergic Hypersensitivity Disease

Allergic Condition

Allergic Reaction

Allergic Disposition

Trigeminal Nerve Disease

Trigeminal Nerve Diseases

Disorders Of 5th Cranial Nerve

Disorders Of The Fifth Cranial Nerve

Constipation
Causalgia

Complex Regional Pain Syndrome, Type Ii

Complex Regional Pain Syndrome Type 2

Taeniasis

Beef Tapeworm Infection

Infection By Taeniarhynchus Saginatus

Taenia Saginata Infectious Disease

Taenia Saginata Infection

Pork Tapeworm Infection

Armed Tapeworm Infection

Infection By Taenia Solium

Intestinal Taenia Solium Infection

Pork Tapeworm

Taenia Solium Taeniasis

Adult Pork Tapeworm Infection

Adult Pork Tapeworm

Beef Tapeworm

Infection By Taenia Saginata

Unarmed Tapeworm Infection

Taenia Saginata Taeniasis

Infection Due To Adult Tapeworm Taenia Saginata

Mediocanellata Taenia Infection

Infestation By Taenia Saginata

Infestation By Taenia Mediocanellata

Pain Agnosia

Analgesia

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor

Psychosomatic Disorder

Psychophysiologic Disorders

Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder

Neurogenic Urinary Bladder Disorder

Neuropathic Bladder

Bladder Neurogenic

Urinary Bladder, Neurogenic

Neurogenic Urinary Bladder

Sudden Infant Death Syndrome

SIDS

Sudden Infant Death Syndrome, Susceptibility To

Cot Death

Crib Death

Sudden Death Of Nonspecific Cause In Infancy

Sudden Infant Death

Death, Sudden, Syndrome, Infant

Epicondylitis

Tennis Elbow

Lateral Epicondylitis

Golfer'S Elbow

Medial Epicondylitis

Andrel Epicondylitis

Archer'S Elbow

Hockey Elbow

Shooter'S Elbow

Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis

Motion Sickness

Airsickness

Carsickness

Seasickness

Travel Sickness

Riders' Vertigo

Paine Syndrome

Pain Disorder

Pain

Microcephaly With Spastic Diplegia

Pain Syndrome

Interstitial Cystitis

Bladder Pain Syndrome

Painful Bladder Syndrome

Ulcerative Cystitis

Ic/Bps

Ic/Pbs

Interstitial Cystitis/Bladder Pain Syndrome

Interstitial Cystitis/Painful Bladder Syndrome

Cystitis, Interstitial

Chronic Interstitial Cystitis

Pelvic Congestion Syndrome

Trigonitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TACR1 RGD RGD:3811
Mus musculus TACR1 MGD MGI:98475
Macaca mulatta TACR1 VGNC VGNC:78083
Canis familiaris TACR1 VGNC VGNC:47066
Felis catus TACR1 VGNC VGNC:65920
Bos taurus TACR1 VGNC VGNC:35560