Tp53 - tumor protein p53 Gene

中文名称：肿瘤蛋白 p53

种属: Rattus norvegicus

同用名: p53; Trp53

关于 Tp53

功能概要

该基因编码肿瘤蛋白 p53，它响应不同的细胞应激以调节诱导细胞周期停滞、细胞凋亡、衰老、DNA 修复或代谢变化的靶基因。 p53 蛋白在正常细胞中以低水平表达，而在各种转化细胞系中以高水平表达，据信它有助于转化和恶性肿瘤。 p53 是一种 DNA 结合蛋白，包含转录激活、DNA 结合和寡聚化结构域。它被假定与 p53 结合位点结合并激活抑制生长和/或侵袭的下游基因的表达，从而起到肿瘤抑制因子的作用。已发现该基因的可变剪接转录本变体，但尚未确定这些变体的生物学有效性。在 9 号和 18 号染色体上发现了 p53 假基因。[RefSeq 提供，2008 年 7 月]

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, Apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it is believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Alternatively spliced transcript variants have been found for this gene, but the biological validity of the variants has not been determined. p53 pseudogenes have been found on chromosomes 9 and 18. [provided by RefSeq, Jul 2008]