2. Gene
  3. NR5A2 - nuclear receptor subfamily 5 group A member 2 Gene

NR5A2 - nuclear receptor subfamily 5 group A member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核受体亚家族 5 组 A 成员 2

种属: Homo sapiens

同用名: B1F; CPF; FTF; B1F2; LRH1; LRH-1; FTZ-F1; hB1F-2; FTZ-F1beta

基因 ID: 2494 | 基因类型: protein coding

关于 NR5A2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,027,710-200,177,415 (from NCBI)

This gene has 6 transcripts (splice variants), 231 orthologues and 1 paralogue. Biased expression in liver (RPKM 6.4), small intestine (RPKM 5.8) and 13 other tissues.

功能概要

由该基因编码的蛋白质是一种结合 DNA 的锌指转录因子，是孤儿核受体 fushi tarazu 因子-1 亚家族的成员。编码的蛋白质参与乙型肝炎病毒和胆固醇生物合成基因的表达，可能是胚胎发育的重要调节因子。[RefSeq 提供，2016 年 6 月]

The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and Cholesterol biosynthesis, and may be an important regulator of embryonic development. [provided by RefSeq, Jun 2016]

NR5A2 基因产物(3)

mRNA Protein Name
NM_001276464.2 NP_001263393.1 nuclear receptor subfamily 5 group A member 2 isoform 3
NM_003822.5 NP_003813.1 nuclear receptor subfamily 5 group A member 2 isoform 2
NM_205860.3 NP_995582.1 nuclear receptor subfamily 5 group A member 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
16289203 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
15205472 GOA
enables nuclear receptor activity IDA
IDA: 通过直接分析推断
15205472 GOA
enables phospholipid binding IDA
IDA: 通过直接分析推断
15723037 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12040021 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16289203 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
15205472 GOA
enables transcription coregulator binding IPI
IPI: 通过物理相互作用推断
14701856 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15143342 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15205472 GOA
involved in positive regulation of viral genome replication IDA
IDA: 通过直接分析推断
19264593 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15723037 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15205472 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15143342 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NR5A2 蛋白结构

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (85 - 152)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (325 - 517)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 541 a.a.
蛋白主名 其他名称

nuclear receptor subfamily 5 group A member 2

CYP7A promoter-binding factor

NR5A2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NR5A2 O00482 EDF1 Homo sapiens O60869
Anti Tag CoIP
12040021
种属间: 跨种属相互作用 种属内: 同种属相互作用

NR5A2 抗体

目录号 产品名 应用 反应物种
HY-P82727 NR5A2 Antibody (YA2472) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Transvestism

Dual-Role Transvestism

Fetishistic Transvestism

Cross Dresser

Transvestic Fetishism
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Fetishism

Fetishism, Psychiatric
46,Xy Sex Reversal 2

Dosage-Sensitive Sex Reversal

Dss

SRXY2

46,Xy Sex Reversal, Dax1-Related

46xy Sex Reversal 2, Dosage-Sensitive

46,Xy Sex Reversal Dax1-Related
46,Xy Sex Reversal

Swyer Syndrome

Pure Gonadal Dysgenesis 46,Xy

Gonadal Dysgenesis, Xy Female Type

Gonadal Dysgenesis, 46,Xy

46,Xy Cgd

46,Xy Complete Gonadal Dysgenesis

46,Xy Pure Gonadal Dysgenesis

46 Xy Gonadal Dysgenesis

46, Xy Cgd

46, Xy Complete Gonadal Dysgenesis

46, Xy Pure Gonadal Dysgenesis

Xy Pure Gonadal Dysgenesis

Female With 46,Xy Karyotype

Xy Females
Idiopathic Peripheral Autonomic Neuropathy
Intrahepatic Cholestasis Of Pregnancy

Recurrent Intrahepatic Cholestasis Of Pregnancy

Gravidic Intrahepatic Cholestasis

Pregnancy-Related Cholestasis

Icp

Pregnancy Related Cholestasis

Cholestasis, Intrahepatic Of Pregnancy

Familial Intrahepatic Cholestasis Of Pregnancy

Familial Recurrent Intrahepatic Cholestasis Of Pregnancy

Ricp

Obstetric Cholestasis
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-115613 ML-180 Agonist 99.06% 否
HY-131445 RJW100 Activator 99.93% 否
HY-RS09554 NR5A2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NR5A2 MGD MGI:1346834
Bos taurus NR5A2 VGNC VGNC:32249
Canis familiaris NR5A2 VGNC VGNC:43956
Felis catus NR5A2 VGNC VGNC:97535
Macaca mulatta NR5A2 VGNC VGNC:75521
Rattus norvegicus NR5A2 RGD RGD:68353
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