2. Gene
  3. FUT3 - fucosyltransferase 3 (Lewis blood group) Gene

FUT3 - fucosyltransferase 3 (Lewis blood group) Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：岩藻糖基转移酶 3 (路易斯血型)

种属: Homo sapiens

同用名: LE; Les; FT3B; CD174; FucT-III

基因 ID: 2525 | 基因类型: protein coding

关于 FUT3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,842,888-5,857,122 (from NCBI)

This gene has 10 transcripts (splice variants), 384 orthologues, 7 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 29.8), esophagus (RPKM 25.0) and 7 other tissues.

功能概要

Lewis 组织血型系统包含一组由外分泌上皮细胞合成并在体液中循环的岩藻糖基化鞘糖脂。糖鞘脂在胚胎发生、组织分化、肿瘤转移、炎症和细菌粘附中起作用。它们二次被红细胞吸收，从而产生 Lewis 表型。该基因是岩藻糖基转移酶家族的成员，在 Lewis 抗原生物合成的最后一步催化岩藻糖添加到前体多糖中。它编码一种具有 alpha (1,3) -岩藻糖基转移酶和 alpha (1,4) -岩藻糖基转移酶活性的酶。该基因的突变是造成大多数 Lewis 抗原阴性表型的原因。该基因表达的差异与宿主对病毒感染的易感性有关。[RefSeq 提供，2020 年 8 月]

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and Bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor Polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an Enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral Infection. [provided by RefSeq, Aug 2020]

FUT3 基因产物(12)

mRNA Protein Name
NM_000149.4 NP_000140.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097639.3 NP_001091108.3 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097640.3 NP_001091109.3 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001097641.3 NP_001091110.3 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001374740.1 NP_001361669.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382744.1 NP_001369673.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382745.1 NP_001369674.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382746.1 NP_001369675.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382747.1 NP_001369676.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382748.2 NP_001369677.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382749.2 NP_001369678.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
NM_001382750.2 NP_001369679.1 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IDA
IDA: 通过直接分析推断
1740457 GOA
enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IMP
IMP: 通过突变表型推断
10211701 GOA
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA
IDA: 通过直接分析推断
1740457 GOA
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IMP
IMP: 通过突变表型推断
10211701 GOA
enables alpha-(1->3)-fucosyltransferase activity IDA
IDA: 通过直接分析推断
1977660 GOA
enables fucosyltransferase activity IDA
IDA: 通过直接分析推断
7721776 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ceramide metabolic process IDA
IDA: 通过直接分析推断
7721776 GOA
involved in fucosylation IDA
IDA: 通过直接分析推断
1977660 GOA
involved in macromolecule glycosylation IDA
IDA: 通过直接分析推断
1977660 GOA
involved in oligosaccharide biosynthetic process IDA
IDA: 通过直接分析推断
1977660 GOA
involved in oligosaccharide metabolic process IDA
IDA: 通过直接分析推断
1740457 GOA
involved in positive regulation of cell-cell adhesion IMP
IMP: 通过突变表型推断
11058871 GOA
involved in protein N-linked glycosylation IDA
IDA: 通过直接分析推断
29593094 GOA
involved in protein O-linked glycosylation IDA
IDA: 通过直接分析推断
29593094 GOA
involved in regulation of cell migration IMP
IMP: 通过突变表型推断
27453266 GOA
involved in regulation of cell population proliferation IMP
IMP: 通过突变表型推断
27453266 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
1977660 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FUT3 蛋白结构

Glyco_transf_10

Glyco_transf_10: Glycosyltransferase family 10 (fucosyltransferase) C-term (16 - 360)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
蛋白主名 其他名称

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase 3

FUT3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FUT3 P21217 TTMP Homo sapiens Q5BVD1
Validated Y2H
32296183
种属内
FUT3 P21217 SLC41A2 Homo sapiens Q96JW4
Validated Y2H
32296183
种属内
FUT3 P21217 FAM3B Homo sapiens P58499
Validated Y2H
32296183
种属内
FUT3 P21217 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Blood Group, Lewis System

LE

Lewis Blood Group System

Les
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05154 FUT3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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