FUT8 - fucosyltransferase 8 Gene

中文名称：岩藻糖基转移酶 8

种属: Homo sapiens

同用名: CDGF; CDGF1

基因 ID: 2530 | 基因类型: protein coding

关于 FUT8

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:65,356,842-65,744,121 (from NCBI)

This gene has 17 transcripts (splice variants), 267 orthologues and is associated with 2 phenotypes. Ubiquitous expression in stomach (RPKM 6.3), brain (RPKM 5.7) and 25 other tissues.

功能概要

该基因编码一种属于岩藻糖基转移酶家族的酶。该基因的产物催化岩藻糖从 GDP-岩藻糖转移到 N-连接型复合糖肽。这种酶不同于其他催化 alpha1-2、alpha1-3 和 alpha1-4 岩藻糖加成的岩藻糖基转移酶。该基因的表达可能有助于癌细胞的恶性及其侵袭和转移能力。可变剪接导致多个转录本变体。[RefSeq 提供，2011 年 5 月]

This gene encodes an Enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This Enzyme is distinct from Other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of Cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

FUT8 基因产物(6)

mRNA	Protein	Name
NM_001371533.1	NP_001358462.1	alpha-(1,6)-fucosyltransferase isoform a
NM_001371534.1	NP_001358463.1	alpha-(1,6)-fucosyltransferase isoform a
NM_001371536.1	NP_001358465.1	alpha-(1,6)-fucosyltransferase isoform c
NM_004480.4	NP_004471.4	alpha-(1,6)-fucosyltransferase isoform b
NM_178155.3	NP_835368.1	alpha-(1,6)-fucosyltransferase isoform a
NM_178156.2	NP_835369.1	alpha-(1,6)-fucosyltransferase isoform a

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables glycoprotein 6-alpha-L-fucosyltransferase activity	IDA IDA: 通过直接分析推断	17172260	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in GDP-L-fucose metabolic process	IDA IDA: 通过直接分析推断	17172260	GOA
involved in protein N-linked glycosylation via asparagine	IDA IDA: 通过直接分析推断	17172260	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FUT8 蛋白结构

SH3_9

0
100
200
300
400
500
575 a.a.

蛋白主名

其他名称

alpha-(1,6)-fucosyltransferase

GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase

FUT8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FUT8	Q9BYC5	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Prey Pooling	32296183
种属内	FUT8	Q9BYC5	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FUT8 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75181	FUT8 Protein, Human (sf9, His)	Q9BYC5-1 (R68-K575)	≥95%

关联疾病

疾病名称

别名

Congenital Disorder Of Glycosylation With Defective Fucosylation 1

CDGF1

Cdgf

Lipodystrophy, Congenital Generalized, Type 2

Congenital Generalized Lipodystrophy Type 2	CGL2
Berardinelli-Seip Congenital Lipodystrophy Type 2	Berardinelli-Seip Syndrome
Brunzell Syndrome Bscl2-Related	Total Lipodystrophy And Acromegaloid Gigantism
Berardinelli-Seip Congenital Lipodystrophy, Type 2	Seip Syndrome
Berardinelli Syndrome	Lipodystrophy, Total, And Acromegaloid Gigantism
Lipoatrophic Diabetes, Congenital	Lipodystrophy, Berardinelli-Seip Congenital, Type 2
Brunzell Syndrome, Bscl2-Related	Congenital Lipoatrophic Diabetes
Congenital Generalized Lipodystrophy 2	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-155747	FDW028	Inhibitor	99.51%	否
HY-E70157	Fucosyltransferase 8		/	否
HY-RS05159	FUT8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P99113A	Inebilizumab (FUT8-KO)		97%	否
HY-P99010A	Bemarituzumab (FUT8-KO)	Inhibitor	/	否
HY-P99406A	Petosemtamab (FUT8-KO)		/	否
HY-P9977A	Amivantamab (FUT8-KO)	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	FUT8	VGNC	VGNC:41015
Bos taurus	FUT8	VGNC	VGNC:29152
Macaca mulatta	FUT8	VGNC	VGNC:72829
Rattus norvegicus	FUT8	RGD	RGD:1303096
Mus musculus	FUT8	MGD	MGI:1858901
Felis catus	FUT8	VGNC	VGNC:62394
Others	FUT8	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FUT8 - fucosyltransferase 8 Gene

关于 FUT8

功能概要

FUT8 基因产物(6)

FUT8 蛋白结构

FUT8 蛋白互作信息

重组 FUT8 蛋白

关联疾病

直系同源

热门区域

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FUT8 - fucosyltransferase 8 Gene

关于 FUT8

功能概要

FUT8 基因产物(6)

FUT8 蛋白结构

FUT8 蛋白互作信息

重组 FUT8 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z