2. Gene
  3. F2r - coagulation factor II (thrombin) receptor Gene

F2r - coagulation factor II (thrombin) receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：凝血因子 II (凝血酶) 受体

种属: Rattus norvegicus

同用名: Par1; TRGPC

基因 ID: 25439 | 基因类型: protein coding

关于 F2r

Primary_assembly 2: 26,868,404-26,885,870 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 330 orthologues, 14 paralogues and is associated with 18 phenotypes. Biased expression in Lung (RPKM 362.8), Adrenal (RPKM 23.8) and 9 other tissues.

功能概要

预计该基因编码的蛋白具有多种功能，包括 G 蛋白 α-亚基结合活性； G蛋白β-亚基结合活性；和凝血酶激活的受体活性。参与多个过程，包括在神经肌肉接头处建立突触特异性；细胞溶质钙离子浓度的正向调节；和蛋白激酶 C 激活 G 蛋白偶联受体信号通路。位于神经肌肉接头和突触后膜。用于研究高血压。脑水肿和脑缺血的生物标志物。与人 F2R（凝血因子 II 凝血酶受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and thrombin-activated receptor activity. Involved in several processes, including establishment of synaptic specificity at neuromuscular junction; positive regulation of cytosolic calcium ion concentration; and protein kinase C-activating G protein-coupled receptor signaling pathway. Located in neuromuscular junction and postsynaptic membrane. Used to study hypertension. Biomarker of brain edema and brain ischemia. Orthologous to human F2R (coagulation factor II Thrombin receptor). [provided by Alliance of Genome Resources, Apr 2022]

F2r 基因产物(1)

mRNA Protein Name
NM_012950.2 NP_037082.2 proteinase-activated receptor 1 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
12372796 RGD
involved in establishment of synaptic specificity at neuromuscular junction IDA
IDA: 通过直接分析推断
12815704 RGD
involved in negative regulation of glomerular filtration IDA
IDA: 通过直接分析推断
12644441 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
11919511 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
12644441 RGD
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
12372796 RGD
involved in positive regulation of calcium ion transport IMP
IMP: 通过突变表型推断
15145074 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
12372796 RGD
involved in positive regulation of smooth muscle contraction IDA
IDA: 通过直接分析推断
14699501 RGD
involved in positive regulation of vasoconstriction IDA
IDA: 通过直接分析推断
12644441 RGD
involved in release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
15145074 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in neuromuscular junction IDA
IDA: 通过直接分析推断
12815704 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
15145074 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
12815704 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

F2r 蛋白结构

7tmA_PAR1

7tmA_PAR1: cd15369 (109 - 388)

7tmA_PAR1

7tmA_PAR1: cd15369 (109 - 136)

7tmA_PAR1

7tmA_PAR1: cd15369 (143 - 168)

7tmA_PAR1

7tmA_PAR1: cd15369 (181 - 211)

7tmA_PAR1

7tmA_PAR1: cd15369 (225 - 243)

7tmA_PAR1

7tmA_PAR1: cd15369 (273 - 302)

7tmA_PAR1

7tmA_PAR1: cd15369 (312 - 342)

7tmA_PAR1

7tmA_PAR1: cd15369 (356 - 381)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
蛋白主名 其他名称

proteinase-activated receptor 1

PAR-1

Thrombin receptor

coagulation factor II receptor

protease-activated receptor 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04631 F2R Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04632 F2r Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04633 F2r Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens F2r NCBI NCBI:2149
Macaca fascicularis F2r NCBI NCBI:102137130
Mus musculus F2r NCBI NCBI:14062
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