F2r - coagulation factor II (thrombin) receptor Gene

中文名称：凝血因子 II (凝血酶) 受体

种属: Rattus norvegicus

同用名: Par1; TRGPC

关于 F2r

功能概要

预计该基因编码的蛋白具有多种功能，包括 G 蛋白 α-亚基结合活性； G蛋白β-亚基结合活性；和凝血酶激活的受体活性。参与多个过程，包括在神经肌肉接头处建立突触特异性；细胞溶质钙离子浓度的正向调节；和蛋白激酶 C 激活 G 蛋白偶联受体信号通路。位于神经肌肉接头和突触后膜。用于研究高血压。脑水肿和脑缺血的生物标志物。与人 F2R（凝血因子 II 凝血酶受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and thrombin-activated receptor activity. Involved in several processes, including establishment of synaptic specificity at neuromuscular junction; positive regulation of cytosolic calcium ion concentration; and protein kinase C-activating G protein-coupled receptor signaling pathway. Located in neuromuscular junction and postsynaptic membrane. Used to study hypertension. Biomarker of brain edema and brain ischemia. Orthologous to human F2R (coagulation factor II Thrombin receptor). [provided by Alliance of Genome Resources, Apr 2022]