F2r - coagulation factor II (thrombin) receptor Gene

中文名称：凝血因子 II (凝血酶) 受体

种属: Mus musculus

同用名: Cf2r; Par1; ThrR

关于 F2r

功能概要

该基因编码的蛋白可启动 G 蛋白偶联受体活性； G蛋白α-亚基结合活性；和 G 蛋白 β-亚基结合活性。参与多个过程，包括肾素分泌到血液中的负调节；细胞内信号转导的正向调节；和内源性大麻素的跨突触信号，调节突触传递。作用于多个过程的上游或内部，包括调节 interleukin-1 beta 的产生；对脂多糖的反应；和凝血酶激活受体信号通路。预计位于几种细胞成分中，包括小窝；核内体；和血小板致密管状网络。预计是质膜的组成部分。以多种结构表达，包括心血管系统；中枢神经系统;外分泌腺；肺;和甲状腺。与人 F2R（凝血因子 II 凝血酶受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in several processes, including negative regulation of Renin secretion into blood stream; positive regulation of intracellular signal transduction; and trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including regulation of interleukin-1 beta production; response to lipopolysaccharide; and thrombin-activated receptor signaling pathway. Predicted to be located in several cellular components, including caveola; endosome; and platelet dense tubular network. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; exocrine gland; lung; and thyroid gland. Orthologous to human F2R (coagulation factor II Thrombin receptor). [provided by Alliance of Genome Resources, Apr 2022]