2. Gene
  3. ICAM1 - Icam1 intercellular adhesion molecule 1 Gene

ICAM1 - Icam1 intercellular adhesion molecule 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: CD54; ICAM

基因 ID: 25464 | 基因类型: protein coding

关于 ICAM1

功能概要

Enables Integrin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and gonad development. Located in cell surface; extracellular space; and plasma membrane. Used to study diabetic angiopathy; mesenteric vascular occlusion; nephritis; pre-eclampsia; and uveitis. Biomarker of several diseases, including cerebrovascular disease (multiple); colitis (multiple); kidney failure (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Orthologous to human ICAM1 (intercellular adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

ICAM1 基因产物(1)

mRNA Protein Name
NM_012967.1 NP_037099.1 intercellular adhesion molecule 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IMP
IMP: 通过突变表型推断
16825578 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
10556544 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acute inflammatory response to antigenic stimulus IMP
IMP: 通过突变表型推断
7641842 RGD
involved in cell-cell adhesion IDA
IDA: 通过直接分析推断
12097510 RGD
involved in cell-cell adhesion IMP
IMP: 通过突变表型推断
8938183 RGD
involved in cellular response to alkaloid IEP
IEP: 通过表达模式推断
20674665 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
10976991 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
20627932 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
20631551 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
20643106 RGD
involved in cellular response to interleukin-6 IEP
IEP: 通过表达模式推断
7865494 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
20674665 RGD
involved in cellular response to nutrient levels IEP
IEP: 通过表达模式推断
20643106 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
15087287 RGD
involved in cellular response to type II interferon IEP
IEP: 通过表达模式推断
7865494 RGD
involved in cellular senescence IEP
IEP: 通过表达模式推断
20421514 RGD
involved in establishment of Sertoli cell barrier IDA
IDA: 通过直接分析推断
22976294 RGD
involved in establishment of endothelial intestinal barrier IMP
IMP: 通过突变表型推断
10201790 RGD
involved in negative regulation of calcium ion transport IDA
IDA: 通过直接分析推断
15087287 RGD
involved in ovarian follicle development IEP
IEP: 通过表达模式推断
20591976 RGD
involved in positive regulation of GTPase activity IDA
IDA: 通过直接分析推断
17662049 RGD
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
9062344 RGD
involved in positive regulation of actin filament polymerization IDA
IDA: 通过直接分析推断
17662049 RGD
involved in positive regulation of leukocyte adhesion to vascular endothelial cell IMP
IMP: 通过突变表型推断
10517906 RGD
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
9062344 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
17662049 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
12296653 RGD
involved in regulation of cell shape IMP
IMP: 通过突变表型推断
15087287 RGD
involved in response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEP
IEP: 通过表达模式推断
20870297 RGD
involved in response to amino acid IEP
IEP: 通过表达模式推断
20599905 RGD
involved in response to amphetamine IEP
IEP: 通过表达模式推断
21093552 RGD
involved in response to copper ion IEP
IEP: 通过表达模式推断
20544302 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
20726338 RGD
involved in response to gonadotropin IEP
IEP: 通过表达模式推断
20591976 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
19823174 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
18791499 RGD
involved in response to ionizing radiation IEP
IEP: 通过表达模式推断
20385203 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
20871155 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
20740350 RGD
involved in response to sulfur dioxide IEP
IEP: 通过表达模式推断
20951496 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
20871620 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
8938183 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
18413153 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

intercellular adhesion molecule 1

ICAM-1

重组 ICAM1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73114 ICAM-1/CD54 Protein, Rat (HEK293, His) Q00238 (Q28-T493) ≥95%
HY-P73909 ICAM-1/CD54 Protein, Rat (HEK293, Fc) Q00238 (Q28-T493) ≥95%

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-19344 Lifitegrast Antagonist 99.29% 否
HY-19344A Lifitegrast sodium Inhibitor 99.33% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-145728 Alicaforsen Inhibitor / Phase 3
HY-145728A Alicaforsen sodium Inhibitor / Phase 3
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99473 Bersanlimab Inhibitor ≥99.0% Phase 2
Pre-clinical Phase
生物活性分子 (26)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-33037 Phenazine-1-carboxylic acid Inhibitor 99.88% 否
HY-100226 A-205804 Inhibitor 98.25% 否
HY-15701 Leukadherin-1 Agonist ≥98.0% 否
HY-110117 BIRT 377 Inhibitor 98.07% 否
HY-P1110 AF12198 Inhibitor 99.75% 否
HY-N0602 Ginsenoside Rg2 Inhibitor 98.11% 否
HY-U00003 ICAM-1-IN-1 Inhibitor 99.93% 否
HY-107587 A-286982 Inhibitor 99.33% 否
HY-W588250 Surfactin C1 Antagonist 99.36% 否
HY-145728B (R/S)-Alicaforsen Inhibitor 97.08% 否
HY-10596 BMS-688521 Inhibitor 98.62% 否
HY-P2508 MUC1, mucin core 99.85% 否
HY-110086 RWJ 50271 Inhibitor 99.25% 否
HY-W013557 3-Hydroxyxanthone Inhibitor ≥98.0% 否
HY-13412 Cariporide (mesilate) Modulator / 否
HY-101961 Tyrphostin AG 1288 Inhibitor 98.68% 否
HY-143243 Antioxidant agent-5 Inhibitor / 否
HY-N0602R Ginsenoside Rg2 (Standard) Inhibitor / 否
HY-N11996 Aloenin aglycone / 否
HY-N4275 Oleaside A / 否
HY-RS06512 ICAM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-122192 ICAM-1988 / 否
HY-127113 Q8 Antagonist / 否
HY-19344S Lifitegrast-d4 / 否
HY-19344S1 Lifitegrast-d6 / 否
HY-19344S2 Lifitegrast-d4-1 Antagonist / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99336 Enlimomab Inhibitor 95.00% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ICAM1 NCBI NCBI:3383
Canis familiaris ICAM1 NCBI NCBI:403975
Macaca mulatta ICAM1 NCBI NCBI:712280
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