2. Anti-infection
  3. Fungal
  4. Phenazine-1-carboxylic acid

Phenazine-1-carboxylic acid  (Synonyms: 吩嗪-1-羧酸)

目录号: HY-33037 纯度: 99.88%
COA 产品使用指南

摩尔计算器

Phenazine-1-carboxylic acid 是一种抗真菌剂。此外，Phenazine-1-carboxylic acid 具有抗癌活性，可通过调节 ROS 生成来诱导癌细胞凋亡。Phenazine-1-carboxylic acid 可上调 IL-8 和 ICAM-1 的表达，同时抑制 RANTES 和 MCP-1 的释放，具有其潜在的免疫调节作用。Phenazine-1-carboxylic acid 在抗感染、抗肿瘤和调节免疫反应方面具有重要的研究价值。

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Phenazine-1-carboxylic acid Chemical Structure

Phenazine-1-carboxylic acid Chemical Structure

CAS No. : 2538-68-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥485
In-stock
25 mg ￥441
In-stock
50 mg ￥621
In-stock
100 mg ￥900
In-stock
250 mg ￥1620
In-stock
500 mg   询价  
1 g   询价  

* Please select Quantity before adding items.

Customer Review

Phenazine-1-carboxylic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation[1][2][3][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
15.6 μM
Compound: 4, Tubermycin B
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 5 days by hemocytometry
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 5 days by hemocytometry
[PMID: 23402329]
体外研究
(In Vitro)

Phenazine-1-carboxylic acid (10-100 µM, 24 小时和 48 小时) 可以时间和剂量依赖的方式有效抑制 DU145 细胞的增殖[2]。
Phenazine-1-carboxylic acid (50 µM, 24 小时) 可通过活性氧生成和线粒体凋亡途径诱导 DU145 细胞凋亡[2]。
Phenazine-1-carboxylic acid (50 µM，36 小时) 可上调 IL-8 和 ICAM-1 表达，抑制 RANTES 和 MCP-1 释放，具有调节免疫反应的潜在活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Phenazine-1-carboxylic acid 相关抗体:

Cell Viability Assay[2]

Cell Line: DU145 prostate cancer cells
Concentration: 10, 25, 50, 75, 100 µM
Incubation Time: 24 and 48 hours
Result: Inhibited DU145 cell proliferation in a time- and dose-dependent manner, with the highest inhibition at the maximum concentration.

Apoptosis Analysis[2]

Cell Line: DU145 prostate cancer cells
Concentration: 50 µM
Incubation Time: 24 hours
Result: Induced reactive oxygen species (ROS) generation in DU145 cells, causing mitochondrial membrane depolarization and apoptosis.
体内研究
(In Vivo)

Phenazine-1-carboxylic acid (2 和 3 µg/mL，通过 E3 培养基添加，单次给药) 可显著预防斑马鱼胚胎中 V. anguillarum 的感染[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish embryos infected with Vibrio anguillarum[4]
Dosage: 2 µg/mL and 3 µg/mL
Administration: Added through zebrafish embryo E3 medium, single dose
Result: Effectively inhibited V. anguillarum infection in zebrafish embryos and increased embryo hatching rate.
分子量

224.21

Formula

C13H8N2O2
CAS 号
性状

固体

颜色

Light yellow to green yellow

结构分类
初始来源

Truncatella angustata
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 5 mg/mL (22.30 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.4601 mL 22.3005 mL 44.6010 mL
5 mM 0.8920 mL 4.4601 mL 8.9202 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.88%

COA (291 KB)

产品使用指南 (1538 KB)
参考文献

Phenazine-1-carboxylic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4601 mL 22.3005 mL 44.6010 mL 111.5026 mL
5 mM 0.8920 mL 4.4601 mL 8.9202 mL 22.3005 mL
10 mM 0.4460 mL 2.2301 mL 4.4601 mL 11.1503 mL
15 mM 0.2973 mL 1.4867 mL 2.9734 mL 7.4335 mL
20 mM 0.2230 mL 1.1150 mL 2.2301 mL 5.5751 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenazine-1-carboxylic acid2538-68-3FungalDU145 prostate cancer cellsZebrafish embryosAnti-cancerInhibitorinhibitorinhibit

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