2. Gene
  3. Stxbp1 - syntaxin binding protein 1 Gene

Stxbp1 - syntaxin binding protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Sec1; nSec1; NSEC1A; n-sec1; rbSec1; ANC18HA; Unc18-1; rbSec1A; rbSec1B; Munc18-1

基因 ID: 25558 | 基因类型: protein coding

关于 Stxbp1

功能概要

Enables several functions, including Enzyme binding activity; identical protein binding activity; and syntaxin-1 binding activity. Involved in several processes, including positive regulation of secretion by cell; positive regulation of vesicle docking; and regulation of protein-containing complex assembly. Acts upstream of or within protein stabilization. Located in several cellular components, including axon; perinuclear region of cytoplasm; and postsynapse. Part of protein-containing complex. Colocalizes with plasma membrane. Human ortholog(s) of this gene implicated in West syndrome and developmental and epileptic encephalopathy 4. Orthologous to human STXBP1 (syntaxin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Stxbp1 基因产物(1)

mRNA Protein Name
NM_013038.4 NP_037170.1 syntaxin-binding protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SNARE binding IDA
IDA: 通过直接分析推断
18201107 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17442889 RGD
enables molecular adaptor activity EXP
EXP: 通过实验结果推断
21193638 RGD
enables phospholipase binding IDA
IDA: 通过直接分析推断
14744865 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9395480 RGD
enables protein domain specific binding IDA
IDA: 通过直接分析推断
19255244 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
12963086 RGD
enables syntaxin binding IDA
IDA: 通过直接分析推断
12506202 RGD
enables syntaxin-1 binding IDA
IDA: 通过直接分析推断
7553862 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in developmental process involved in reproduction IMP
IMP: 通过突变表型推断
16951547 RGD
involved in negative regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
12093152 RGD
involved in positive regulation of exocytosis IMP
IMP: 通过突变表型推断
20801887 RGD
involved in positive regulation of glutamate secretion, neurotransmission IMP
IMP: 通过突变表型推断
16951547 RGD
involved in positive regulation of mast cell degranulation IMP
IMP: 通过突变表型推断
23487749 RGD
involved in positive regulation of vesicle docking IDA
IDA: 通过直接分析推断
22810233 RGD
acts upstream of or within protein stabilization IDA
IDA: 通过直接分析推断
15935055 RGD
involved in regulation of synaptic vesicle priming IDA
IDA: 通过直接分析推断
21689256 RGD
involved in regulation of synaptic vesicle priming IMP
IMP: 通过突变表型推断
19255244 RGD
involved in regulation of vesicle fusion IDA
IDA: 通过直接分析推断
24532794 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
16951547 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
15869823 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
17442889 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15869823 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
17442889 RGD
located in postsynapse IDA
IDA: 通过直接分析推断
15869823 RGD
located in presynapse IDA
IDA: 通过直接分析推断
15869823 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
19255244 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

syntaxin-binding protein 1

p67

protein unc-18 homolog 1

protein unc-18 homolog A

unc-18 homolog

unc-18-1

unc-18A

Stxbp1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Stxbp1 P61765 Apba2 Rattus norvegicus O35431
Y2H
9395480
种属内
Stxbp1 P61765 Stx1a Rattus norvegicus P32851
Crosslink
17301226
种属内
Stxbp1 P61765 Stx1a Rattus norvegicus P32851
ITC
18337752
种属内
Stxbp1 P61765 Stx1a Rattus norvegicus P32851
Fluorescence
18337752
种属间
Stxbp1 P61765 Stx4 Mus musculus P70452
ITC
21193638
种属间
Stxbp1 P61765 Stx4 Mus musculus P70452
X-Ray Diffraction
21193638
种属内
Stxbp1 P61765 Apba1 Rattus norvegicus O35430
Y2H
9395480
种属内
Stxbp1 P61765 Apba1 Rattus norvegicus O35430
Pull Down
9395480
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13989 STXBP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stxbp1 NCBI NCBI:6812
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