Stx1a - syntaxin 1A Gene

种属: Rattus norvegicus

基因 ID: 116470 | 基因类型: protein coding

关于 Stx1a

功能概要

Enables several functions, including ATP-dependent protein binding activity; calcium-dependent protein binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; positive regulation of secretion by cell; and synaptic vesicle exocytosis. Located in several cellular components, including actomyosin; presynaptic active zone membrane; and secretory vesicle. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in glutamatergic synapse. Is integral component of presynaptic membrane and integral component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Apr 2022]

Stx1a 基因产物(1)

mRNA	Protein	Name
NM_053788.3	NP_446240.2	syntaxin-1A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP-dependent protein binding	IPI IPI: 通过物理相互作用推断	16030255	RGD
enables SNARE binding	IDA IDA: 通过直接分析推断	7553862	RGD
enables SNARE binding	IPI IPI: 通过物理相互作用推断	7698987	RGD
enables calcium-dependent protein binding	IPI IPI: 通过物理相互作用推断	16030255	RGD
enables myosin binding	IPI IPI: 通过物理相互作用推断	16030255	RGD
enables myosin head/neck binding	IPI IPI: 通过物理相互作用推断	16030255	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	8567678	RGD
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	16030255	RGD
enables protein-macromolecule adaptor activity	IPI IPI: 通过物理相互作用推断	16030255	RGD
enables transmembrane transporter binding	IPI IPI: 通过物理相互作用推断	17301173	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in SNARE complex assembly	IMP IMP: 通过突变表型推断	9671503	RGD
involved in modulation of excitatory postsynaptic potential	IMP IMP: 通过突变表型推断	18703708	RGD
involved in positive regulation of calcium ion-dependent exocytosis	IDA IDA: 通过直接分析推断	17301173	RGD
involved in positive regulation of catecholamine secretion	IDA IDA: 通过直接分析推断	20484665	RGD
involved in positive regulation of exocytosis	IDA IDA: 通过直接分析推断	11331586	RGD
involved in positive regulation of neurotransmitter secretion	IMP IMP: 通过突变表型推断	12183029	RGD
involved in positive regulation of norepinephrine secretion	IDA IDA: 通过直接分析推断	18167541	RGD
involved in protein localization to membrane	IDA IDA: 通过直接分析推断	12093152	RGD
involved in regulation of exocytosis	IMP IMP: 通过突变表型推断	16030255	RGD
involved in response to gravity	IDA IDA: 通过直接分析推断	15076716	RGD
involved in synaptic vesicle docking	IEP IEP: 通过表达模式推断	1321498	RGD
involved in synaptic vesicle exocytosis	EXP EXP: 通过实验结果推断	7901002	RGD
involved in synaptic vesicle exocytosis	IDA IDA: 通过直接分析推断	7901002	RGD
involved in synaptic vesicle exocytosis	IEP IEP: 通过表达模式推断	7901002	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in Schaffer collateral - CA1 synapse	IDA IDA: 通过直接分析推断	26903802	RGD
located in actomyosin	IDA IDA: 通过直接分析推断	16030255	RGD
is active in glutamatergic synapse	EXP EXP: 通过实验结果推断	7901002	RGD
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	7901002	RGD
located in plasma membrane	IDA IDA: 通过直接分析推断	17301173	RGD
is active in postsynaptic density membrane	IDA IDA: 通过直接分析推断	26903802	RGD
is active in presynaptic active zone membrane	IDA IDA: 通过直接分析推断	26903802	RGD
is active in presynaptic membrane	IDA IDA: 通过直接分析推断	8301329	RGD
located in presynaptic membrane	IDA IDA: 通过直接分析推断	12093152	RGD
part of protein-containing complex	IDA IDA: 通过直接分析推断	19255244	RGD
located in secretory granule	IDA IDA: 通过直接分析推断	15537656	RGD
is active in synaptic vesicle membrane	IDA IDA: 通过直接分析推断	7860636	RGD
located in synaptic vesicle membrane	IDA IDA: 通过直接分析推断	14645230	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA IDA: 通过直接分析推断	7553862	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IMP IMP: 通过突变表型推断	9671503	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	IDA IDA: 通过直接分析推断	7553862	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	IDA IDA: 通过直接分析推断	19132534	RGD
part of voltage-gated potassium channel complex	IDA IDA: 通过直接分析推断	17301173	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

syntaxin-1A

P35A	neuron-specific antigen HPC-1
synaptotagmin-associated 35 kDa protein	syntaxin 1A (brain)
syntaxin 1A (brain)-like

Stx1a 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Stx1a	P32851	SNAP47	Homo sapiens	Q5SQN1	Confocal	26359495
种属间	Stx1a	P32851	SNAP47	Homo sapiens	Q5SQN1	Anti Tag CoIP	26359495
种属内	Stx1a	P32851	Snap25	Rattus norvegicus	P60881	Pull Down	21193638
种属内	Stx1a	P32851	Snap25	Rattus norvegicus	P60881	Anti Bait CoIP	17717530
种属内	Stx1a	P32851	Snap25	Rattus norvegicus	P60881	EPR	26876096
种属内	Stx1a	P32851	Snap25	Rattus norvegicus	P60881	Anti Bait CoIP	20489724
种属内	Stx1a	P32851	Snap25	Rattus norvegicus	P60881	Pull Down	10373452
种属内	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	EPR	26876096
种属内	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	X-Ray Diffraction	10746715
种属内	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	Fluorescence	18337752
种属内	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	ITC	21193638
种属内	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	Anti Tag CoIP	26359495
种属内	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	ITC	18337752
种属内	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	Pull Down	21193638
种属内	Stx1a	P32851	Snap25	Rattus norvegicus	P60881-2	FRET	18275821
种属内	Stx1a	P32851	Cadps	Rattus norvegicus	Q62717	Density Sedimentation	19805029
种属间	Stx1a	P32851	Snap25	Mus musculus	P60879	Comigration in SDS	19805029
种属间	Stx1a	P32851	Snap25	Mus musculus	P60879	Anti Bait CoIP	19703397
种属内	Stx1a	P32851	Vamp2	Rattus norvegicus	P63045	Pull Down	21193638

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13980	STX1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Stx1a	NCBI	NCBI:6804

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Stx1a - syntaxin 1A Gene

关于 Stx1a

功能概要

Stx1a 基因产物(1)

Stx1a 蛋白互作信息

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Stx1a - syntaxin 1A Gene

关于 Stx1a

功能概要

Stx1a 基因产物(1)

Stx1a 蛋白互作信息

相关产品

直系同源

热门区域

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B

C

F

G

H

J

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Q

S

T

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