Snap25 - synaptosomal-associated protein 25 Gene

种属: Mus musculus

同用名: sp; Bdr; SUP; GENA70; SNAP-25

基因 ID: 20614 | 基因类型: protein coding

关于 Snap25

功能概要

Enables syntaxin-1 binding activity. Involved in exocytosis; neurotransmitter receptor internalization; and regulation of neuron projection development. Acts upstream of or within several processes, including associative learning; neurotransmitter secretion; and regulation of synaptic plasticity. Located in several cellular components, including glutamatergic synapse; synaptic vesicle; and trans-Golgi network. Is extrinsic component of cytoplasmic side of plasma membrane. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Is expressed in adrenal gland; jaw; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; obesity; schizophrenia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Apr 2022]

Snap25 基因产物(24)

mRNA	Protein	Name
NM_001291056.2	NP_001277985.1	synaptosomal-associated protein 25 isoform b
NM_001355254.1	NP_001342183.1	synaptosomal-associated protein 25 isoform a
NM_001355255.2	NP_001342184.1	synaptosomal-associated protein 25 isoform c
NM_001412615.1	NP_001399544.1	synaptosomal-associated protein 25 isoform a
NM_001412616.1	NP_001399545.1	synaptosomal-associated protein 25 isoform a
NM_001412617.1	NP_001399546.1	synaptosomal-associated protein 25 isoform b
NM_001412618.1	NP_001399547.1	synaptosomal-associated protein 25 isoform c
NM_001412619.1	NP_001399548.1	synaptosomal-associated protein 25 isoform d
NM_001412620.1	NP_001399549.1	synaptosomal-associated protein 25 isoform d
NM_001412621.1	NP_001399550.1	synaptosomal-associated protein 25 isoform e
NM_001412622.1	NP_001399551.1	synaptosomal-associated protein 25 isoform f
NM_011428.4	NP_035558.1	synaptosomal-associated protein 25 isoform a
NM_001291056.2	NP_001277985.1	synaptosomal-associated protein 25 isoform b
NM_001355254.1	NP_001342183.1	synaptosomal-associated protein 25 isoform a
NM_001355255.2	NP_001342184.1	synaptosomal-associated protein 25 isoform c
NM_001412615.1	NP_001399544.1	synaptosomal-associated protein 25 isoform a
NM_001412616.1	NP_001399545.1	synaptosomal-associated protein 25 isoform a
NM_001412617.1	NP_001399546.1	synaptosomal-associated protein 25 isoform b
NM_001412618.1	NP_001399547.1	synaptosomal-associated protein 25 isoform c
NM_001412619.1	NP_001399548.1	synaptosomal-associated protein 25 isoform d
NM_001412620.1	NP_001399549.1	synaptosomal-associated protein 25 isoform d
NM_001412621.1	NP_001399550.1	synaptosomal-associated protein 25 isoform e
NM_001412622.1	NP_001399551.1	synaptosomal-associated protein 25 isoform f
NM_011428.4	NP_035558.1	synaptosomal-associated protein 25 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables SNAP receptor activity	IDA IDA: 通过直接分析推断	12145198	MGI
enables SNARE binding	IDA IDA: 通过直接分析推断	12145198	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	16565726	MGI
enables syntaxin-1 binding	IDA IDA: 通过直接分析推断	18703708	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within associative learning	IMP IMP: 通过突变表型推断	23064108	MGI
acts upstream of or within locomotory behavior	IMP IMP: 通过突变表型推断	23064108	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: 通过突变表型推断	23395379	MGI
acts upstream of or within neurotransmitter secretion	IMP IMP: 通过突变表型推断	11753414	MGI
involved in presynaptic dense core vesicle exocytosis	IDA IDA: 通过直接分析推断	28404788	MGI
involved in presynaptic dense core vesicle exocytosis	IEP IEP: 通过表达模式推断	28404788	MGI
involved in presynaptic dense core vesicle exocytosis	IMP IMP: 通过突变表型推断	28404788	MGI
acts upstream of or within regulation of establishment of protein localization	IMP IMP: 通过突变表型推断	23395379	MGI
involved in regulation of neuron projection development	IGI IGI: 通过遗传相互作用推断	21986494	MGI
involved in synaptic vesicle exocytosis	IDA IDA: 通过直接分析推断	17728451	MGI
involved in synaptic vesicle exocytosis	IMP IMP: 通过突变表型推断	17728451	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in axon	IDA IDA: 通过直接分析推断	21576241	MGI
located in cell cortex	IDA IDA: 通过直接分析推断	23821748	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	19546860	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	17728451	MGI
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	17728451	MGI
located in membrane	IDA IDA: 通过直接分析推断	19546860	MGI
located in neuron projection	IDA IDA: 通过直接分析推断	14622145	MGI
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	18827011	MGI
located in presynaptic membrane	IDA IDA: 通过直接分析推断	24680688	MGI
located in ribbon synapse	IDA IDA: 通过直接分析推断	24680688	MGI
located in somatodendritic compartment	IDA IDA: 通过直接分析推断	21576241	MGI
located in synapse	IDA IDA: 通过直接分析推断	10712642	MGI
located in synaptic vesicle	IDA IDA: 通过直接分析推断	24680688	MGI
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	IDA IDA: 通过直接分析推断	21040848	MGI
located in trans-Golgi network	IDA IDA: 通过直接分析推断	18827011	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

synaptosomal-associated protein 25

blind drunk	super protein
synaptosomal-associated 25 kDa protein	synaptosomal-associated protein, 25 kDa

Snap25 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Snap25	P60879	Cenpf	Mus musculus	Q155P7	Anti Bait CoIP	16672379
种属内	Snap25	P60879	Cenpf	Mus musculus	Q155P7	Fluorescence	18827011
种属内	Snap25	P60879	Cenpf	Mus musculus	Q155P7	Confocal	16672379
种属内	Snap25	P60879	Cenpf	Mus musculus	Q155P7	Y2H	16672379
种属内	Snap25	P60879	Cenpf	Mus musculus	Q155P7	Anti Tag CoIP	16672379
种属内	Snap25	P60879	Stx1a	Mus musculus	O35526	Anti Bait CoIP	20114047
种属内	Snap25	P60879	Stx1a	Mus musculus	O35526	Anti Bait CoIP	24705552
种属内	Snap25	P60879	Vamp2	Mus musculus	P63044	Comigration in SDS	19703397
种属内	Snap25	P60879	Vamp2	Mus musculus	P63044	Anti Bait CoIP	24705552
种属内	Snap25	P60879	Vamp2	Mus musculus	P63044	Anti Bait CoIP	20114047
种属内	Snap25	P60879	Vamp2	Mus musculus	P63044	Comigration in SDS	19805029
种属内	Snap25	P60879	Vamp2	Mus musculus	P63044	Anti Bait CoIP	20798282
种属内	Snap25	P60879	Vamp2	Mus musculus	P63044	Density Sedimentation	16565726
种属间	Snap25	P60879	Stx1a	Rattus norvegicus	P32851	Affinity Techniques	19703397
种属间	Snap25	P60879	Stx1a	Rattus norvegicus	P32851	Density Sedimentation	16565726
种属间	Snap25	P60879	Stx1a	Rattus norvegicus	P32851	Comigration in SDS	19703397
种属间	Snap25	P60879	Stx1a	Rattus norvegicus	P32851	Comigration in SDS	19805029

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13474	SNAP25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Snap25	NCBI	NCBI:6616

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Snap25 - synaptosomal-associated protein 25 Gene

关于 Snap25

功能概要

Snap25 基因产物(24)

Snap25 蛋白互作信息

直系同源

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Snap25 - synaptosomal-associated protein 25 Gene

关于 Snap25

功能概要

Snap25 基因产物(24)

Snap25 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z