2. Gene
  3. Pkm - pyruvate kinase M1/2 Gene

Pkm - pyruvate kinase M1/2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：丙酮酸激酶 M1 /2

种属: Rattus norvegicus

同用名: PK; Pk3; Pkm2; PKM12

基因 ID: 25630 | 基因类型: protein coding

关于 Pkm

Primary_assembly 8: 60,057,402-60,079,599 forward strand.mRatBN7.2:CM026981.1

This gene has 4 transcripts (splice variants), 229 orthologues, 5 paralogues and is associated with 10 phenotypes. Biased expression in Muscle (RPKM 9449.2), Heart (RPKM 2392.1) and 6 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 ADP 绑定活动；丙酮酸激酶活性；和甲状腺激素结合活性。参与多个过程，包括ATP生物合成过程；动物器官再生；和丙酮酸代谢过程。丙酮酸激酶复合物的一部分。与人类 PKM（丙酮酸激酶 M1/2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ADP binding activity; Pyruvate Kinase activity; and thyroid hormone binding activity. Involved in several processes, including ATP biosynthetic process; animal organ regeneration; and pyruvate metabolic process. Part of Pyruvate Kinase complex. Orthologous to human PKM (Pyruvate Kinase M1/2). [provided by Alliance of Genome Resources, Apr 2022]

Pkm 基因产物(1)

mRNA Protein Name
NM_053297.2 NP_445749.1 pyruvate kinase PKM
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ADP binding IDA
IDA: 通过直接分析推断
7040662 RGD
enables identical protein binding IDA
IDA: 通过直接分析推断
1883388 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17877381 RGD
enables protein dimerization activity IDA
IDA: 通过直接分析推断
11687968 RGD
enables pyruvate kinase activity IDA
IDA: 通过直接分析推断
1883388 RGD
enables thyroid hormone binding IDA
IDA: 通过直接分析推断
1883388 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in animal organ regeneration IDA
IDA: 通过直接分析推断
4005043 RGD
involved in glucose metabolic process IDA
IDA: 通过直接分析推断
7929251 RGD
involved in glycolytic process IDA
IDA: 通过直接分析推断
1883388 RGD
involved in liver development IDA
IDA: 通过直接分析推断
7327170 RGD
involved in protein homotetramerization IDA
IDA: 通过直接分析推断
10734049 RGD
involved in protein tetramerization IDA
IDA: 通过直接分析推断
11687968 RGD
involved in pyruvate biosynthetic process IDA
IDA: 通过直接分析推断
4273555 RGD
involved in pyruvate metabolic process IDA
IDA: 通过直接分析推断
10734049 RGD
involved in response to gravity IEP
IEP: 通过表达模式推断
12165359 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
3696161 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
7929251 RGD
involved in response to muscle inactivity IEP
IEP: 通过表达模式推断
6331066 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
7929251 RGD
involved in skeletal muscle tissue regeneration IDA
IDA: 通过直接分析推断
145474 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of pyruvate kinase complex IDA
IDA: 通过直接分析推断
1883388 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pkm 蛋白结构

Pyruvate_Kinase

Pyruvate_Kinase: cd00288 (101 - 589)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 591 a.a.
蛋白主名 其他名称

pyruvate kinase PKM

M2 pyruvate kinase

pyruvate kinase isozymes M1/M2

pyruvate kinase muscle isozyme

pyruvate kinase, muscle

threonine-protein kinase PKM2

tyrosine-protein kinase PKM2

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P1284 ZIP Inhibitor 95.72% Phase 4
HY-P1284A ZIP TFA Inhibitor / Phase 4
Pre-clinical Phase
生物活性分子 (35)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0822 Shikonin Inhibitor 99.80% 否
HY-18657 TEPP-46 Activator 99.93% 否
HY-103617 PKM2-IN-1 Inhibitor 99.79% 否
HY-19330 DASA-58 Activator 99.73% 否
HY-126585 SAICAR 99.36% 否
HY-147368 PKM2 activator 2 Activator 99.48% 否
HY-D1456 TEPC466 99.43% 否
HY-N2552 Vitamin K5 hydrochloride 98.00% 否
HY-139667 PKM2-IN-3 Inhibitor 99.44% 否
HY-157913 PKM2-IN-6 99.77% 否
HY-148324 PKM2 activator 5 Activator 96.24% 否
HY-155850 CIAC001 Inhibitor 99.70% 否
HY-P1399A Pep2m, myristoylated TFA Inhibitor 99.77% 否
HY-D1876 ZY-2 95.77% 否
HY-156375 PKM2 activator 6 / 否
HY-119874 Alkannin Inhibitor / 否
HY-126585S SAICAR-d1 / 否
HY-147397 PKM2 activator 3 Activator / 否
HY-148313 PKM2 activator 4 Activator / 否
HY-148615 NPD10084 Inhibitor / 否
HY-149275 PKM2/PDK1-IN-1 / 否
HY-155216 PKM2 activator 10 / 否
HY-155668 HMG-CoA Reductase-IN-1 Inhibitor / 否
HY-155785 MTP / 否
HY-161519 PKM2 activator 7 Activator / 否
HY-167832 PT109 Inhibitor / 否
HY-B1814 Vitamin K5 / 否
HY-D1877 ZY-1 98.91% 否
HY-P1399 Pep2m, myristoylated Inhibitor / 否
HY-RS10602 PKM Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10603 Pkm Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10604 Pkm Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-121275 Benserazide Inhibitor / 否
HY-155849 PKM2-IN-4 Inhibitor / 否
HY-162071 PKM2-IN-5 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pkm NCBI NCBI:5315
Mus musculus Pkm NCBI NCBI:18746
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