2. Gene
  3. Cntf - ciliary neurotrophic factor Gene

Cntf - ciliary neurotrophic factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 25707 | 基因类型: protein coding

关于 Cntf

功能概要

Enables ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in several processes, including membrane hyperpolarization; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including axon; neuronal cell body; and plasma membrane bounded cell projection cytoplasm. Used to study Huntington's disease and glaucoma. Biomarker of hyperglycemia and retinitis pigmentosa. Human ortholog(s) of this gene implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Cntf 基因产物(1)

mRNA Protein Name
NM_013166.2 NP_037298.2 ciliary neurotrophic factor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ciliary neurotrophic factor receptor binding IPI
IPI: 通过物理相互作用推断
1648265 RGD
enables cytokine activity IDA
IDA: 通过直接分析推断
8385113 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
8385113 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in astrocyte activation IDA
IDA: 通过直接分析推断
11771938 RGD
involved in axon regeneration IDA
IDA: 通过直接分析推断
16699509 RGD
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
15342787 RGD
involved in membrane hyperpolarization IDA
IDA: 通过直接分析推断
15831538 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
15574731 RGD
involved in nervous system development IDA
IDA: 通过直接分析推断
11932952 RGD
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
15574731 RGD
involved in positive regulation of axon regeneration IDA
IDA: 通过直接分析推断
15574731 RGD
involved in positive regulation of cell growth IDA
IDA: 通过直接分析推断
11771938 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15831538 RGD
involved in positive regulation of hormone secretion IDA
IDA: 通过直接分析推断
11771938 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
15574731 RGD
involved in positive regulation of protein modification process IDA
IDA: 通过直接分析推断
14725620 RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
15574731 RGD
involved in regulation of resting membrane potential IDA
IDA: 通过直接分析推断
15831538 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
19576889 RGD
involved in response to light intensity IEP
IEP: 通过表达模式推断
21076359 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
12849744 RGD
located in glial cell projection IDA
IDA: 通过直接分析推断
14725620 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
12849744 RGD
located in plasma membrane bounded cell projection cytoplasm IDA
IDA: 通过直接分析推断
12849744 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ciliary neurotrophic factor

ciliary neurotropic factor

重组 Cntf 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7148 CNTF Protein, Rat P20294 (A2-M200) ≥95%
HY-P7148A CNTF Protein, Rat (His) P20294 (A2-M200) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02923 CNTF Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cntf NCBI NCBI:1270
Mus musculus Cntf NCBI NCBI:12803
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