1. Gene
  2. Plcg1 - phospholipase C, gamma 1 Gene

Plcg1 - phospholipase C, gamma 1 Gene

种属: Rattus norvegicus

同用名: PPLCA

基因 ID: 25738 | 基因类型: protein coding

关于 Plcg1

功能概要

Enables Insulin Receptor binding activity; Phospholipase C activity; and phosphoprotein binding activity. Involved in several processes, including inositol trisphosphate biosynthetic process; regulation of store-operated Calcium Channel activity; and response to morphine. Located in clathrin-coated vesicle. Colocalizes with neuron projection. Orthologous to human PLCG1 (Phospholipase C gamma 1). [provided by Alliance of Genome Resources, Apr 2022]

Plcg1 基因产物(1)

mRNA Protein Name
NM_013187.2 NP_037319.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium-dependent phospholipase C activity IDA
IDA: 通过直接分析推断
7531435 RGD
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
15252117 RGD
enables insulin receptor binding IDA
IDA: 通过直接分析推断
14568990 RGD
enables phosphatidylinositol phospholipase C activity IDA
IDA: 通过直接分析推断
7531435 RGD
enables phosphoprotein binding IPI
IPI: 通过物理相互作用推断
8910399 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10077576 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium ion transport IMP
IMP: 通过突变表型推断
12437926 RGD
involved in epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
7531435 RGD
involved in inositol trisphosphate biosynthetic process IMP
IMP: 通过突变表型推断
16973916 RGD
involved in inositol trisphosphate metabolic process IDA
IDA: 通过直接分析推断
7812955 RGD
involved in phosphatidylinositol catabolic process IDA
IDA: 通过直接分析推断
7812955 RGD
involved in phosphatidylinositol metabolic process IDA
IDA: 通过直接分析推断
7531435 RGD
involved in positive regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
16973916 RGD
involved in regulation of store-operated calcium channel activity IMP
IMP: 通过突变表型推断
17432954 RGD
involved in response to curcumin IDA
IDA: 通过直接分析推断
7812955 RGD
involved in response to gravity IEP
IEP: 通过表达模式推断
17404041 RGD
involved in response to hydrogen peroxide IEP
IEP: 通过表达模式推断
17982259 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in clathrin-coated vesicle IDA
IDA: 通过直接分析推断
11779129 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

PLC-148

PLC-II

PLC-gamma-1

phosphoinositide phospholipase C

phosphoinositide phospholipase C-gamma-1

Plcg1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Plcg1 P10686 FGFR1 Homo sapiens P11362
X-Ray Diffraction
19665973
种属内
Plcg1 P10686 Fgfr1 Rattus norvegicus Q04589
ITC
19665973
种属间
Plcg1 P10686 TRPC3 Homo sapiens Q13507
Y2H
15744307
种属间
Plcg1 P10686 Jak2 Mus musculus Q62120
IF
17128263
种属间
Plcg1 P10686 Jak2 Mus musculus Q62120
Anti Tag CoIP
17128263
种属间
Plcg1 P10686 Khdrbs2 Mus musculus Q9WU01
Pull Down
10077576
种属间
Plcg1 P10686 PTPN1 Homo sapiens P18031
Anti Tag CoIP
17128263
种属间
Plcg1 P10686 PTPN1 Homo sapiens P18031
IF
17128263
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Plcg1 NCBI NCBI:5335