TAB3 - TGF-beta activated kinase 1 (MAP3K7) binding protein 3 Gene

中文名称：TGF-β 活化激酶 1 (MAP3K7) 结合蛋白 3

种属: Homo sapiens

同用名: NAP1; MAP3K7IP3

关于 TAB3

功能概要

该基因的产物在 NF-kappaB 信号转导通路中起作用。编码的蛋白质以及类似且功能冗余的蛋白质 MAP3K7IP2/TAB2 与蛋白激酶 MAP3K7/TAK1 和 TRAF2 或 TRAF6 形成三元复合物，以响应促炎细胞因子 TNF 或 IL-1 的刺激。随后的 MAP3K7/TAK1 激酶活性触发信号级联，导致 NF-kappaB 转录因子的激活。人类基因组包含一个相关的假基因。已经描述了选择性剪接的转录本变体，但尚未确定它们的生物学有效性。[RefSeq 提供，2008 年 7 月]

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]