FBXO7 - F-box protein 7 Gene

中文名称：F-box 蛋白 7

种属: Homo sapiens

同用名: FBX; FBX7; PKPS; FBX07; PARK15

基因 ID: 25793 | 基因类型: protein coding

关于 FBXO7

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:32,474,811-32,498,829 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 94.0), thyroid (RPKM 68.7) and 25 other tissues.

功能概要

该基因编码 F-box 蛋白家族的一个成员，其特征在于大约 40 个氨基酸基序，即 F-box。 F-box 蛋白构成称为 SCF (SKP1-cullin-F-box) 的泛素蛋白连接酶复合物的四个亚基之一，其在磷酸化依赖性泛素化中发挥作用。 F-box 蛋白分为 3 类：包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和包含不同蛋白质-蛋白质相互作用模块或无可识别基序的 Fbxs。该基因编码的蛋白质属于 Fbxs 类，可能在造血调节中发挥作用。该基因的可变剪接转录变体已被鉴定，仅确定了一些变体的全长性质。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]

FBXO7 基因产物(3)

mRNA	Protein	Name
NM_001033024.2	NP_001028196.1	F-box only protein 7 isoform 2
NM_001257990.2	NP_001244919.1	F-box only protein 7 isoform 3
NM_012179.4	NP_036311.3	F-box only protein 7 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15145941	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	18495667	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	18495667	GOA
enables ubiquitin binding	IDA IDA: 通过直接分析推断	25029497	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	16510124	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: 通过直接分析推断	15145941	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in autophagy of mitochondrion	IMP IMP: 通过突变表型推断	23933751	GOA
acts upstream of negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IDA IDA: 通过直接分析推断	26310625	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	25029497	GOA
involved in positive regulation of mitophagy	IDA IDA: 通过直接分析推断	26310625	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	36646384	GOA
involved in protein K48-linked ubiquitination	IDA IDA: 通过直接分析推断	36646384	GOA
involved in protein targeting to mitochondrion	IMP IMP: 通过突变表型推断	23933751	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	16510124	GOA
involved in protein ubiquitination	IMP IMP: 通过突变表型推断	23933751	GOA
involved in regulation of locomotion	IDA IDA: 通过直接分析推断	26310625	GOA
involved in regulation of neuron projection development	IMP IMP: 通过突变表型推断	25029497	GOA
involved in regulation of protein stability	IDA IDA: 通过直接分析推断	15145941	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	25029497	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Lewy body core	IDA IDA: 通过直接分析推断	23656991	GOA
located in Lewy body corona	IDA IDA: 通过直接分析推断	23656991	GOA
located in Lewy neurite	IDA IDA: 通过直接分析推断	23656991	GOA
part of SCF ubiquitin ligase complex	IDA IDA: 通过直接分析推断	15145941	GOA
located in classical Lewy body	IDA IDA: 通过直接分析推断	23656991	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	16510124	GOA
located in cytosol	IDA IDA: 通过直接分析推断	18495667	GOA
located in glial cytoplasmic inclusion	IDA IDA: 通过直接分析推断	23656991	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	23933751	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	36646384	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16510124	GOA
part of ubiquitin ligase complex	IDA IDA: 通过直接分析推断	23933751	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FBXO7 蛋白结构

PI31_Prot_N

F-box-like

0
100
200
300
400
522 a.a.

蛋白主名

其他名称

F-box only protein 7

FBXO7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	FBXO7	Q9Y3I1	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	FBXO7	Q9Y3I1	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	FBXO7	Q9Y3I1	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	FBXO7	Q9Y3I1	PINK1	Homo sapiens	Q9BXM7	Pull Down	23933751
Intra	FBXO7	Q9Y3I1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	28514442
Intra	FBXO7	Q9Y3I1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	16278047
Intra	FBXO7	Q9Y3I1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	26496610
Intra	FBXO7	Q9Y3I1	SKP1	Homo sapiens	P63208	Anti Tag CoIP	22632967
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Validated Y2H	25910212
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Y2H Prey Pooling	25416956
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Y2H Bait-Prey Pool	25910212
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Y2H Array	25910212
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	FBXO7	Q9Y3I1	PSMA3	Homo sapiens	P25788	Y2H Array	25416956
Intra	FBXO7	Q9Y3I1	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	FBXO7	Q9Y3I1	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	FBXO7	Q9Y3I1	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	FBXO7	Q9Y3I1	PSME3	Homo sapiens	P61289	Y2H Array	25416956
Intra	FBXO7	Q9Y3I1	PRKN	Homo sapiens	O60260	Pull Down	23933751
Intra	FBXO7	Q9Y3I1	PRKN	Homo sapiens	O60260	Anti Tag CoIP	23933751
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Y2H Array	25416956
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Validated Y2H	25910212
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Y2H Bait-Prey Pool	25910212
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Validated Y2H	25416956
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Anti Tag CoIP	33961781
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Y2H Array	31515488
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Anti Tag CoIP	26496610
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Anti Tag CoIP	28514442
Intra	FBXO7	Q9Y3I1	PSMF1	Homo sapiens	Q92530	Y2H Array	25910212

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome	Pallidopyramidal Syndrome
Parkinson Disease 15, Autosomal Recessive	PARK15
Pkps	Pallido-Pyramidal Syndrome
Parkinson'S Disease 15	Autosomal Recessive Early-Onset Parkinson Disease 15
Autosomal Recessive Early-Onset Parkinson'S Disease 15	Pallido-Pyramidal Disease
Parkinson Disease 15	Parkinson Disease 15 Autosomal Recessive
Pps	Parkinson Disease, Type 15

Early-Onset Parkinson'S Disease

Early-Onset Parkinson Disease

Kufor-Rakeb Syndrome

Park9	Krppd
KRS	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia
Autosomal Recessive Parkinson Disease 9	Parkinson Disease 9
Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset	Autosomal Recessive Juvenile Onset Parkinson Disease 9
Parkinson Disease Type 9	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia
Park 9	Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis
Cln12 Disease	Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis
Parkinson Disease Autosomal Recessive 9

Parkinson Disease 3, Autosomal Dominant

PARK3	Parkinson Disease 3
Parkinson Disease 3, Autosomal Dominant Lewy Body	Parkinson'S Disease 3
Autosomal Dominant Lewy Body Parkinson Disease 3	Autosomal Dominant Parkinson Disease 3
Parkinson Disease Type 3	Autosomal Dominant Parkinson Disease
Parkinson Disease, Autosomal Dominant	Parkinson Disease, Familial, Type 1

Pyromania

Firesetting Behavior	Pathological Firesetting
Pathological Fire-Setting

Vertebrobasilar Insufficiency

Vertebro-Basilar Insufficiency	Vertebrobasilar Arterial Insufficiency
Vertebrobasilar Artery Syndrome

Meier-Gorlin Syndrome 3

MGORS3

Meier-Gorlin Syndrome, Type 3

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Neurodegeneration With Brain Iron Accumulation 2b

NBIA2B	Neurodegeneration With Brain Iron Accumulation, Pla2g6-Related
Neuroaxonal Dystrophy, Atypical	Karak Syndrome
Atypical Neuroaxonal Dystrophy	Neurodegeneration With Brain Iron Accumulation Pla2g6-Related
Neurodegeneration, With Brain Iron Accumulation, Type 2b	Neurodegeneration With Brain Iron Accumulation 2

Perry Syndrome

Parkinsonism With Alveolar Hypoventilation And Mental Depression

PERRYS

Vascular Parkinsonism

Neuroaxonal Dystrophy

Neuroaxonal Dystrophies

Movement Disease

Movement Disorders

Movement Disorder

Gaucher'S Disease

Gaucher Disease	Kerasin Thesaurismosis
Glucocerebrosidase Deficiency	Glucosylceramidase Deficiency
Cerebroside Lipidosis Syndrome	Acid Beta-Glucosidase Deficiency
Glucosylceramide Beta-Glucosidase Deficiency	Acute Cerebral Gaucher Disease
Gaucher Splenomegaly	Glucocerebrosidosis
Glucosyl Cerebroside Lipidosis	Kerasin Lipoidosis
Lipoid Histiocytosis	Glocucerebrosidase Deficiency
Sphingolipidosis 1	Gaucher Syndrome
Gauchers Disease	Gd
Glucosylceramide Lipidosis	Kerasin Histiocytosis
Gaucher Disease, Type 1	Gaucher Disease, Type 2

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04813	FBXO7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	FBXO7	VGNC	VGNC:40789
Macaca mulatta	FBXO7	VGNC	VGNC:72491
Bos taurus	FBXO7	VGNC	VGNC:28919
Felis catus	FBXO7	VGNC	VGNC:62198
Rattus norvegicus	FBXO7	RGD	RGD:1305648
Mus musculus	FBXO7	MGD	MGI:1917004

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FBXO7 - F-box protein 7 Gene

关于 FBXO7

功能概要

FBXO7 基因产物(3)

FBXO7 蛋白结构

FBXO7 蛋白互作信息

关联疾病

直系同源

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FBXO7 - F-box protein 7 Gene

关于 FBXO7

功能概要

FBXO7 基因产物(3)

FBXO7 蛋白结构

FBXO7 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

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Q

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