2. Gene
  3. KLK5 - kallikrein related peptidase 5 Gene

KLK5 - kallikrein related peptidase 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：激肽释放酶相关肽酶 5

种属: Homo sapiens

同用名: SCTE; KLKL2; KLK-L2

基因 ID: 25818 | 基因类型: protein coding

关于 KLK5

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:50,943,303-50,953,038 (from NCBI)

This gene has 5 transcripts (splice variants), 107 orthologues and 12 paralogues. Biased expression in skin (RPKM 70.7), lung (RPKM 6.1) and 1 other tissue.

功能概要

激肽释放酶是具有不同生理功能的丝氨酸蛋白酶的一个亚组。越来越多的证据表明，许多激肽释放酶与致癌作用有关，有些具有作为新型癌症和其他疾病生物标志物的潜力。该基因是位于 19 号染色体簇中的 15 个激肽释放酶亚家族成员之一。其表达受雌激素和孕激素的上调。编码的蛋白质被分泌出来，可能参与表皮的脱屑。可变剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2008 年 7 月]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

KLK5 基因产物(3)

mRNA Protein Name
NM_001077491.2 NP_001070959.1 kallikrein-5 preproprotein
NM_001077492.2 NP_001070960.1 kallikrein-5 preproprotein
NM_012427.5 NP_036559.1 kallikrein-5 preproprotein

KLK5 蛋白结构

Trypsin

Trypsin: Trypsin (67 - 285)

  • 0
  • 100
  • 200
  • 293 a.a.
蛋白主名 其他名称

kallikrein-5

kallikrein-like protein 2

KLK5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KLK5 Q9Y337 FLG Homo sapiens P20930
Protease Assay
23629652
种属内
KLK5 Q9Y337 MANBAL Homo sapiens Q9NQG1
Y2H Prey Pooling
32296183
种属内
KLK5 Q9Y337 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 KLK5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70939 Kallikrein-5 Protein, Human (HEK293, His) Q9Y337 (V23-S293) ≥95%

KLK5 抗体

目录号 产品名 应用 反应物种
HY-P83144 Kallikrein 5 Antibody (YA2889) WB, ICC/IF, FC Human, Mouse

关联疾病

疾病名称 别名
Netherton Syndrome

NETH

Ns

Netherton Disease

Comel-Netherton Syndrome

Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

Bamboo Hair Syndrome

Ichthyosis Linearis Circumflexa

Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

Ilc

Nts

N Syndrome
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Telangiectasis

Telangiectasia
Ichthyosis, Congenital, Autosomal Recessive 4b

Harlequin Ichthyosis

Autosomal Recessive Congenital Ichthyosis 4b

Hi

Harlequin Fetus

ARCI4B

Ichthyosis Congenita, Harlequin Fetus Type

Harlequin Type Ichthyosis

'Harlequin Fetus'

Harlequin Type Ichthyosis Congenita

Harlequin Type Ichthyosis Fetalis

Harlequin Baby Syndrome

Ichthyosis Congenita, Harlequin Type

Ichthyosis Fetalis, Harlequin Type

Ichthyosis Congenita Harlequin Fetus Type

Ichthyosis, Harlequin

Ichthyosis, Congenital, Autosomal Recessive, Type 4b
Ichthyosis Vulgaris

Ichthyosis Simplex

Dominant Congenital Ichthyosiform Erythroderma

Common Ichthyosis

Fish Scale Disease

VI

Ichthyoses

Congenital Ichthyosis
Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis

Congenital Ichthyosiform Erythroderma

Li

Congenital Nonbullous Ichthyosiform Erythroderma

Arci

Congenital Lamellar Ichthyosis

Nonbullous Congenital Ichthyosiform Erythroderma

Cie

Congenital Non-Bullous Ichthyosiform Erythroderma

Erythrodermic Ichthyosis

Nbcie

Ncie

Non-Bullous Congenital Ichthyosiform Erythroderma

Collodion Baby

Ichthyosis, Lamellar

Non Bullous Congenital Ichthyosiform Erythroderma

Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

Collodion Baby Syndrome

Ichthyoses, Lamellar

Nbie

Nonbullous Ichthyosiform Erythroderma

Classic Lamellar Ichthyosis

Ichthyosiform Erythroderma Nonbullous Congenital

Ichthyosiform Erythroderma Congenital

Ichthyosis, Congenital, Autosomal Recessive

Ichthyosiform Erythroderma, Congenital

Collodion Fetus

Non-Bullous Ichthyosiform Erythroderma
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148949A Kallikrein 5-IN-2 TFA Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris KLK5 VGNC VGNC:42483
Mus musculus KLK5 MGD MGI:1915918
Felis catus KLK5 VGNC VGNC:67965
Rattus norvegicus KLK5 RGD RGD:1593461
Macaca mulatta KLK5 VGNC VGNC:74191
Bos taurus KLK5 VGNC VGNC:30679
Others KLK5 NCBI
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