ARIH1 - ariadne RBR E3 ubiquitin protein ligase 1 Gene

中文名称：ariadne RBR E3 泛素蛋白连接酶 1

种属: Homo sapiens

同用名: ARI; HARI; HHARI; UBCH7BP

基因 ID: 25820 | 基因类型: protein coding

关于 ARIH1

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:72,474,330-72,602,987 (from NCBI)

This gene has 10 transcripts (splice variants), 231 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 22.0), thyroid (RPKM 13.4) and 25 other tissues.

功能概要

启用酶结合活性；泛素蛋白转移酶活性；和锌离子结合活性。参与蛋白质泛素化。位于路易体；细胞质；和核体。与 cullin-RING 泛素连接酶复合物共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables Enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in Lewy body; cytoplasm; and nuclear body. Colocalizes with cullin-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

ARIH1 基因产物(1)

mRNA	Protein	Name
NM_005744.5	NP_005735.2	E3 ubiquitin-protein ligase ARIH1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10521492	GOA
enables ubiquitin conjugating enzyme binding	IPI IPI: 通过物理相互作用推断	23707686	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	11278816	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	14623119	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	15236971	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	14623119	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
NOT part of Cul2-RING ubiquitin ligase complex	IDA IDA: 通过直接分析推断	27565346	GOA
part of Cul2-RING ubiquitin ligase complex	IDA IDA: 通过直接分析推断	24076655	GOA
part of Cul3-RING ubiquitin ligase complex	IDA IDA: 通过直接分析推断	24076655	GOA
part of Cul4A-RING E3 ubiquitin ligase complex	IDA IDA: 通过直接分析推断	24076655	GOA
located in Lewy body	IDA IDA: 通过直接分析推断	21590270	GOA
part of SCF ubiquitin ligase complex	IDA IDA: 通过直接分析推断	24076655	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	11278816	GOA
located in nuclear body	IDA IDA: 通过直接分析推断	23059369	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARIH1 蛋白结构

zf-C3HC4_2

IBR

0
100
200
300
400
500
557 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase ARIH1

ARI-1

ARIH1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036-1	ITC	23707686
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036-1	Pull Down	21532592
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036-1	GMS	23707686
Intra	ARIH1	Q9Y4X5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	33961781
Intra	ARIH1	Q9Y4X5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	24076655
Intra	ARIH1	Q9Y4X5	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	28514442
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036	Anti Tag CoIP	24076655
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036	Anti Tag CoIP	33961781
Intra	ARIH1	Q9Y4X5	UBE2L3	Homo sapiens	P68036	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cerebrovascular Disease

Cerebrovascular Disorder	Cerebrovascular Accident
Cerebrovascular Disorders	Cva
Stroke

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00975	ARIH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-164476	ES-072		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ARIH1	MGD	MGI:1344363
Felis catus	ARIH1	VGNC	VGNC:68178
Macaca mulatta	ARIH1	VGNC	VGNC:84308
Rattus norvegicus	ARIH1	RGD	RGD:1308131
Bos taurus	ARIH1	VGNC	VGNC:26133
Canis familiaris	ARIH1	VGNC	VGNC:38102

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ARIH1 - ariadne RBR E3 ubiquitin protein ligase 1 Gene

关于 ARIH1

功能概要

ARIH1 基因产物(1)

ARIH1 蛋白结构

ARIH1 蛋白互作信息

关联疾病

直系同源

热门区域

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ARIH1 - ariadne RBR E3 ubiquitin protein ligase 1 Gene

关于 ARIH1

功能概要

ARIH1 基因产物(1)

ARIH1 蛋白结构

ARIH1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z