DNAJB5 - DnaJ heat shock protein family (Hsp40) member B5 Gene

中文名称：DnaJ 热休克蛋白家族 (Hsp40) 成员 B5

种属: Homo sapiens

同用名: Hsc40

基因 ID: 25822 | 基因类型: protein coding

关于 DNAJB5

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,989,745-34,998,900 (from NCBI)

This gene has 12 transcripts (splice variants), 281 orthologues and 11 paralogues. Broad expression in heart (RPKM 17.5), brain (RPKM 13.1) and 21 other tissues.

功能概要

该基因编码 DNAJ 热休克蛋白 40 家族的一个成员。编码的蛋白质包含一个 N 端 DNAJ 结构域和一个 C 端底物结合结构域，但缺少在其他 DNAJ 家族成员中发现的富含半胱氨酸的结构域。在小鼠中，含有这种蛋白质、硫氧还蛋白 1 和组蛋白脱乙酰酶 4 的多蛋白复合物充当心脏肥大的主要负调节因子。[RefSeq 提供，2017 年 3 月]

This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in Other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017]

DNAJB5 基因产物(6)

mRNA	Protein	Name
NM_001135004.3	NP_001128476.3	dnaJ homolog subfamily B member 5 isoform 2
NM_001135005.3	NP_001128477.1	dnaJ homolog subfamily B member 5 isoform 1
NM_001349723.3	NP_001336652.1	dnaJ homolog subfamily B member 5 isoform 1
NM_001349724.2	NP_001336653.1	dnaJ homolog subfamily B member 5 isoform 3
NM_001349725.2	NP_001336654.2	dnaJ homolog subfamily B member 5 isoform 2
NM_012266.6	NP_036398.3	dnaJ homolog subfamily B member 5 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18457437	GOA
enables protein-folding chaperone binding	IPI IPI: 通过物理相互作用推断	21231916	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in response to unfolded protein	IEP IEP: 通过表达模式推断	10570961	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	21231916	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DNAJB5 蛋白结构

DnaJ

DnaJ_C

0
100
200
300
348 a.a.

蛋白主名

其他名称

dnaJ homolog subfamily B member 5

DnaJ (Hsp40) homolog, subfamily B, member 5

DNAJB5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DNAJB5	O75953	TTN	Homo sapiens	Q8WZ42	Y2H Fragment Pooling	23414517
种属内	DNAJB5	O75953	CACNA1A	Homo sapiens	O00555	Pull Down	21078624

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Skeletal Muscle Disease

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Fatal Infantile Hypertonic Myofibrillar Myopathy

Borjeson-Forssman-Lehmann Syndrome

BFLS	Borj
Borjeson Syndrome	Mrxsbfl
Intellectual Deficiency-Epilepsy-Endocrine Disorders Syndrome	Intellectual Disability-Epilepsy-Endocrine Disorders Syndrome
Mental Retardation, X-Linked, Syndromic, Borjeson-Forssman-Lehmann Type	Mental Retardation, Epilepsy, And Endocrine Disorders
Mental Retardation, Epilepsy, And Endocrine Disorder	Syndromic X-Linked Mental Retardation Borjeson-Forssman-Lehmann Type
Mental Deficiency, Epilepsy And Endocrine Disorders	Boerjeson-Forssman-Lehmann Syndrome
Borjeson-Forssman Syndrome	Mental Deficiency-Epilepsy- Endocrine Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03868	DNAJB5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	DNAJB5	VGNC	VGNC:51709
Felis catus	DNAJB5	VGNC	VGNC:102921
Rattus norvegicus	DNAJB5	RGD	RGD:1307453
Macaca mulatta	DNAJB5	VGNC	VGNC:103256
Mus musculus	DNAJB5	MGD	MGI:1930018
Bos taurus	DNAJB5	VGNC	VGNC:56945

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4