2. Gene
  3. PRDX5 - peroxiredoxin 5 Gene

PRDX5 - peroxiredoxin 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：过氧化物酶 5

种属: Homo sapiens

同用名: PLP; ACR1; B166; PRXV; PMP20; PRDX6; prx-V; SBBI10; AOEB166; HEL-S-55

基因 ID: 25824 | 基因类型: protein coding

关于 PRDX5

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,318,121-64,321,811 (from NCBI)

This gene has 3 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in colon (RPKM 157.0), kidney (RPKM 130.3) and 25 other tissues.

功能概要

该基因编码抗氧化酶过氧化物酶家族的成员，可减少过氧化氢和烷基氢过氧化物。编码的蛋白质与过氧化物酶体受体 1 相互作用，在正常条件下和炎症过程中在不同组织中发挥抗氧化保护作用。使用替代转录起始位点被认为会导致转录变体使用不同的框内翻译起始密码子来生成靶向线粒体 (同种型 L) 或过氧化物酶体/细胞质 (同种型 S) 的同种型。已经为这个基因定义了多个相关的假基因。[RefSeq 提供，2017 年 11 月]

This gene encodes a member of the peroxiredoxin family of antioxidant Enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]

PRDX5 基因产物(5)

mRNA Protein Name
NM_001358511.2 NP_001345440.2 peroxiredoxin-5, mitochondrial isoform d precursor
NM_001358516.2 NP_001345445.1 peroxiredoxin-5, mitochondrial isoform S
NM_012094.5 NP_036226.2 peroxiredoxin-5, mitochondrial isoform L precursor
NM_181651.3 NP_857634.2 peroxiredoxin-5, mitochondrial isoform b precursor
NM_181652.3 NP_857635.2 peroxiredoxin-5, mitochondrial isoform c precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase III transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10095767 GOA
enables antioxidant activity IDA
IDA: 通过直接分析推断
10514471 GOA
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
IMP: 通过突变表型推断
18262354 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15046979 GOA
enables peroxidase activity IDA
IDA: 通过直接分析推断
10521424 GOA
enables peroxynitrite reductase activity IDA
IDA: 通过直接分析推断
15280035 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10514471 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
10514471 GOA
enables thioredoxin peroxidase activity EXP
EXP: 通过实验结果推断
15280035 GOA
enables thioredoxin peroxidase activity IDA
IDA: 通过直接分析推断
10751410 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NADPH oxidation IDA
IDA: 通过直接分析推断
10751410 GOA
involved in cellular response to reactive oxygen species IMP
IMP: 通过突变表型推断
18262354 GOA
involved in hydrogen peroxide catabolic process IDA
IDA: 通过直接分析推断
10514471 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
18262354 GOA
involved in negative regulation of oxidoreductase activity IDA
IDA: 通过直接分析推断
15280035 GOA
involved in negative regulation of transcription by RNA polymerase III IDA
IDA: 通过直接分析推断
10095767 GOA
involved in positive regulation of collagen biosynthetic process IDA
IDA: 通过直接分析推断
15276323 GOA
involved in reactive nitrogen species metabolic process IDA
IDA: 通过直接分析推断
15280035 GOA
involved in regulation of apoptosis involved in tissue homeostasis IDA
IDA: 通过直接分析推断
15276323 GOA
involved in response to oxidative stress IDA
IDA: 通过直接分析推断
10514471 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10514471 GOA
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
10095767 GOA
located in cytosol IDA
IDA: 通过直接分析推断
18262354 GOA
located in intracellular membrane-bounded organelle IDA
IDA: 通过直接分析推断
15785239 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
10521424 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10095767 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10095767 GOA
located in peroxisomal matrix IDA
IDA: 通过直接分析推断
10514471 GOA
located in peroxisome IDA
IDA: 通过直接分析推断
10521424 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRDX5 蛋白结构

Redoxin

Redoxin: Redoxin (57 - 199)

  • 0
  • 100
  • 200
  • 214 a.a.
蛋白主名 其他名称

peroxiredoxin-5, mitochondrial

Alu co-repressor 1

PRDX5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PRDX5 P30044 NUFIP2 Homo sapiens Q7Z417
Validated Y2H
32296183
种属内
PRDX5 P30044 NUFIP2 Homo sapiens Q7Z417
Y2H Array
32296183
种属内
PRDX5 P30044 NUFIP2 Homo sapiens Q7Z417
Y2H Prey Pooling
32296183
种属内
PRDX5 P30044 CDKN2D Homo sapiens P55273
Validated Y2H
32296183
种属内
PRDX5 P30044 SMCP Homo sapiens P49901
Validated Y2H
32296183
种属内
PRDX5 P30044 SMCP Homo sapiens P49901
Y2H Prey Pooling
32296183
种属内
PRDX5 P30044 SMCP Homo sapiens P49901
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRDX5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71146 PRDX5/Peroxiredoxin-5 Protein, Human (HEK293, His) P30044-1 (M53-L214) ≥95%
HY-P73711 PRDX5/Peroxiredoxin-5 Protein, Human (His) P30044-1 (M53-L214) ≥95%

关联疾病

疾病名称 别名
Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1
Parkinson Disease 7, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 7

PARK7

Parkinson'S Disease 7

Autosomal Recessive Early-Onset Parkinson'S Disease 7

Parkinson Disease 7

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2

Autosomal Recessive Early-Onset Parkinson Disease Type 7

Parkinson Disease, Type 7
Acatalasemia

Acatalasia

Catalase Deficiency

Deficiency Of Catalase

ACATLAS

Takahara'S Disease

Takahara Disease
Alopecia Areata

Aa

Alopecia Celsi

Alopecia Circumscripta

Cazenave'S Vitiligo

Celsus' Vitiligo

Diffuse Alopecia

Jonston'S Alopecia

Marginal Alopecia

Pseudopelade

Circumscribed Alopecia

Alopecia Cicatrisata

Patchy Alopecia

Alopecia

Aa - [Alopecia Areata]

Pelade
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1

Vitiligo

VAMAS1

Slev1

Vtlg

Systemic Lupus Erythematosus, Vitiligo-Related

Vitiligo-Associated Multiple Autoimmune Disease 1

Systemic Lupus Erythematosus Vitiligo-Related
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11078 PRDX5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PRDX5 MGD MGI:1859821
Bos taurus PRDX5 VGNC VGNC:33303
Rattus norvegicus PRDX5 RGD RGD:71007
Macaca mulatta PRDX5 VGNC VGNC:101384
Others PRDX5 NCBI
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