PRDX5 - peroxiredoxin 5 Gene

中文名称：过氧化物酶 5

种属: Homo sapiens

同用名: PLP; ACR1; B166; PRXV; PMP20; PRDX6; prx-V; SBBI10; AOEB166; HEL-S-55

基因 ID: 25824 | 基因类型: protein coding

关于 PRDX5

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,318,121-64,321,811 (from NCBI)

This gene has 3 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in colon (RPKM 157.0), kidney (RPKM 130.3) and 25 other tissues.

功能概要

该基因编码抗氧化酶过氧化物酶家族的成员，可减少过氧化氢和烷基氢过氧化物。编码的蛋白质与过氧化物酶体受体 1 相互作用，在正常条件下和炎症过程中在不同组织中发挥抗氧化保护作用。使用替代转录起始位点被认为会导致转录变体使用不同的框内翻译起始密码子来生成靶向线粒体 (同种型 L) 或过氧化物酶体/细胞质 (同种型 S) 的同种型。已经为这个基因定义了多个相关的假基因。[RefSeq 提供，2017 年 11 月]

This gene encodes a member of the peroxiredoxin family of antioxidant Enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]

PRDX5 基因产物(5)

mRNA	Protein	Name
NM_001358511.2	NP_001345440.2	peroxiredoxin-5, mitochondrial isoform d precursor
NM_001358516.2	NP_001345445.1	peroxiredoxin-5, mitochondrial isoform S
NM_012094.5	NP_036226.2	peroxiredoxin-5, mitochondrial isoform L precursor
NM_181651.3	NP_857634.2	peroxiredoxin-5, mitochondrial isoform b precursor
NM_181652.3	NP_857635.2	peroxiredoxin-5, mitochondrial isoform c precursor

PRDX5 蛋白结构

Redoxin

0
100
200
214 a.a.

蛋白主名

其他名称

peroxiredoxin-5, mitochondrial

Alu co-repressor 1

重组 PRDX5 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71146	PRDX5/Peroxiredoxin-5 Protein, Human (HEK293, His)	P30044-1 (M53-L214)	≥95%
HY-P73711	PRDX5/Peroxiredoxin-5 Protein, Human (His)	P30044-1 (M53-L214)	≥95%

关联疾病

疾病名称

别名

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Parkinson Disease 7, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 7	PARK7
Parkinson'S Disease 7	Autosomal Recessive Early-Onset Parkinson'S Disease 7
Parkinson Disease 7	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2
Autosomal Recessive Early-Onset Parkinson Disease Type 7	Parkinson Disease, Type 7

Acatalasemia

Acatalasia	Catalase Deficiency
Deficiency Of Catalase	ACATLAS
Takahara'S Disease	Takahara Disease

Alopecia Areata

Aa	Alopecia Celsi
Alopecia Circumscripta	Cazenave'S Vitiligo
Celsus' Vitiligo	Diffuse Alopecia
Jonston'S Alopecia	Marginal Alopecia
Pseudopelade	Circumscribed Alopecia
Alopecia Cicatrisata	Patchy Alopecia
Alopecia	Aa - [Alopecia Areata]
Pelade

Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1

Vitiligo	VAMAS1
Slev1	Vtlg
Systemic Lupus Erythematosus, Vitiligo-Related	Vitiligo-Associated Multiple Autoimmune Disease 1
Systemic Lupus Erythematosus Vitiligo-Related

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11078	PRDX5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PRDX5	MGD	MGI:1859821
Bos taurus	PRDX5	VGNC	VGNC:33303
Rattus norvegicus	PRDX5	RGD	RGD:71007
Macaca mulatta	PRDX5	VGNC	VGNC:101384
Others	PRDX5	NCBI

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