PRKD2 - protein kinase D2 Gene

中文名称：蛋白激酶 D2

种属: Homo sapiens

同用名: PKD2; HSPC187; nPKC-D2

基因 ID: 25865 | 基因类型: protein coding

关于 PRKD2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,674,316-46,717,114 (from NCBI)

This gene has 17 transcripts (splice variants), 190 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 19.7), lymph node (RPKM 14.5) and 25 other tissues.

功能概要

该基因编码的蛋白质属于丝氨酸/苏氨酸蛋白激酶的蛋白激酶 D (PKD) 家族。这种激酶可以被佛波醇酯以及胃泌素通过胃癌细胞中的胆囊收缩素 B 受体 (CCKBR) 激活。它可以与反式高尔基体网络 (TGN) 中的二酰甘油 (DAG) 结合，并可能调节基底外侧膜蛋白从 TGN 中退出。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by Gastrin via the cholecystokinin B receptor (CCKBR) in gastric Cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PRKD2 基因产物(4)

mRNA	Protein	Name
NM_001079880.2	NP_001073349.1	serine/threonine-protein kinase D2 isoform A
NM_001079881.2	NP_001073350.1	serine/threonine-protein kinase D2 isoform A
NM_001079882.2	NP_001073351.1	serine/threonine-protein kinase D2 isoform B
NM_016457.5	NP_057541.2	serine/threonine-protein kinase D2 isoform A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17962809	GOA
enables protein kinase C binding	IPI IPI: 通过物理相互作用推断	28428613	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	17077180	GOA
enables protein serine kinase activity	IGI IGI: 通过遗传相互作用推断	20497126	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	18440775	GOA
enables protein serine/threonine kinase activity	IMP IMP: 通过突变表型推断	28428613	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in T cell receptor signaling pathway	IDA IDA: 通过直接分析推断	17077180	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IGI IGI: 通过遗传相互作用推断	20497126	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IMP IMP: 通过突变表型推断	18059339	GOA
involved in intracellular signal transduction	IMP IMP: 通过突变表型推断	18059339	GOA
involved in peptidyl-serine phosphorylation	IMP IMP: 通过突变表型推断	28428613	GOA
involved in peptidyl-threonine phosphorylation	IMP IMP: 通过突变表型推断	28428613	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	19192391	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	15604256	GOA
involved in positive regulation of angiogenesis	IGI IGI: 通过遗传相互作用推断	20497126	GOA
involved in positive regulation of angiogenesis	IMP IMP: 通过突变表型推断	18440775	GOA
involved in positive regulation of blood vessel endothelial cell migration	IGI IGI: 通过遗传相互作用推断	20497126	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: 通过突变表型推断	18440775	GOA
involved in positive regulation of cell adhesion	IMP IMP: 通过突变表型推断	17951978	GOA
involved in positive regulation of endothelial cell chemotaxis	IGI IGI: 通过遗传相互作用推断	20497126	GOA
involved in positive regulation of endothelial cell chemotaxis	IMP IMP: 通过突变表型推断	18440775	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: 通过突变表型推断	19001381	GOA
involved in positive regulation of endothelial cell proliferation	IGI IGI: 通过遗传相互作用推断	20497126	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: 通过突变表型推断	19001381	GOA
involved in positive regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	19001381	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: 通过突变表型推断	16928771	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17077180	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	20497126	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	18059339	GOA
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	19001381	GOA
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	17077180	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	22228765	GOA
involved in regulation of T cell apoptotic process	IMP IMP: 通过突变表型推断	17077180	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IGI IGI: 通过遗传相互作用推断	20497126	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	18059339	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17077180	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17077180	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKD2 蛋白结构

C1_1

Pkinase

0
200
400
600
800
878 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase D2

PRKD2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRKD2	Q9BZL6	HDAC7	Homo sapiens	Q8WUI4	Anti Tag CoIP	17962809
种属内	PRKD2	Q9BZL6	HDAC7	Homo sapiens	Q8WUI4	Pull Down	17962809
种属内	PRKD2	Q9BZL6	HDAC7	Homo sapiens	Q8WUI4	Anti Bait CoIP	17962809
种属内	PRKD2	Q9BZL6	HDAC7	Homo sapiens	Q8WUI4	Protein Kinase Assay	17962809
种属内	PRKD2	Q9BZL6	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRKD2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74615	Protein Kinase D2/PRKD2 Protein, Human (sf9, His-GST)	Q9BZL6-1/ NP_057541.2 (M1-L878)	≥95%

关联疾病

疾病名称

别名

Angiolipoma

Conventional Lipoma

Classic Type Lipoma

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11147	PRKD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PRKD2	MGD	MGI:2141917
Macaca mulatta	PRKD2	VGNC	VGNC:76273
Bos taurus	PRKD2	VGNC	VGNC:33337
Canis familiaris	PRKD2	VGNC	VGNC:44987
Felis catus	PRKD2	VGNC	VGNC:64356
Rattus norvegicus	PRKD2	RGD	RGD:1308054
Others	PRKD2	NCBI

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