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  2. GALR1 - galanin receptor 1 Gene

GALR1 - galanin receptor 1 Gene

中文名称:甘丙肽受体 1

种属: Homo sapiens

同用名: GALNR; GALNR1

基因 ID: 2587 | 基因类型: protein coding

关于 GALR1

Cytogenetic location: 18q23 Genomic coordinates (GRCh38): 18:77,249,848-77,277,900 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues and 16 paralogues. Biased expression in adrenal (RPKM 1.2), brain (RPKM 0.7) and 7 other tissues.

功能概要

神经肽甘丙肽通过与特定的 G 蛋白偶联受体相互作用而引发一系列生物学效应。甘丙肽受体是七次跨膜蛋白,可激活多种细胞内第二信使通路。 GALR1 通过 Gi/Go 家族的 G 蛋白抑制腺苷酸环化酶。 GALR1 在大脑和脊髓以及小肠和心脏等外周部位广泛表达。[RefSeq 提供,2008 年 7 月]

The neuropeptide Galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]

GALR1 基因产物(1)

mRNA Protein Name
NM_001480.4 NP_001471.2 galanin receptor type 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables galanin receptor activity IDA
IDA: 通过直接分析推断
24517231 GOA
enables peptide hormone binding IDA
IDA: 通过直接分析推断
24517231 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23597562 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cortisol secretion IMP
IMP: 通过突变表型推断
17982695 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
24517231 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GALR1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 303)

  • 0
  • 100
  • 200
  • 300
  • 349 a.a.
蛋白主名 其他名称

galanin receptor type 1

GAL1-R

GALR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GALR1 P47211 P22466-PRO_0000010449 Homo sapiens P22466-PRO_0000010449
SPA
23597562
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chromosome 18q Deletion Syndrome

18q- Syndrome

Monosomy 18q

Deletion Of Long Arm Of Chromosome 18

Chromosome 18q- Syndrome

Deletion 18q

18q Deletion Syndrome

Distal 18q Deletion Syndrome

Chromosome 18 Long Arm Deletion Syndrome

Chromosome 18q Monosomy

Del Syndrome

Chromosome 18 Deletion Syndrome

Auditory Agnosia
Benign Essential Hypertension
Mood Disorder

Mood Disorders

Episodic Mood Disorder

Lynch Syndrome I

Lynch Syndrome 1

Colorectal Cancer, Hereditary Nonpolyposis, Type 1

HNPCC1

Fcc1

Lynch Syndrome Ii

Colon Cancer, Familial Nonpolyposis, Type 1

Coca1

Familial Nonpolyposis Colon Cancer Type 1

Hereditary Nonpolyposis Colorectal Cancer Type 1

Hereditary Non-Polyposis Colorectal Cancer 1

Hereditary Non-Polyposis Colorectal Cancer 3

Hnpcc3

Lynch Cancer Family Syndrome

Lynch Syndrome

Lynch Syndrome Type I

Lynch Syndrome Type Ii

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1

Hereditary Nonpolyposis Colorectal Cancer

Colorectal Cancer, Hereditary Nonpolyposis, Type 3

Hereditary Non-Polyposis Colon Cancer Type 2

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus GALR1 VGNC VGNC:29239
Canis familiaris GALR1 VGNC VGNC:41100
Macaca mulatta GALR1 VGNC VGNC:104222
Mus musculus GALR1 MGD MGI:1096364
Rattus norvegicus GALR1 RGD RGD:2656
Felis catus GALR1 VGNC VGNC:62456