SUMF2 - sulfatase modifying factor 2 Gene

中文名称：硫酸酯酶修饰因子 2

种属: Homo sapiens

同用名: pFGE

关于 SUMF2

功能概要

硫酸酯酶的催化位点只有在含有独特的氨基酸 C-α-甲酰甘氨酸 (FGly) 时才有活性。 FGly 残基是通过具有 FGly 生成活性的酶从半胱氨酸翻译后生成的。该记录中描述的基因是硫酸酯酶修饰因子家族的一员，编码一种具有 DUF323 结构域的蛋白质，该结构域定位于内质网腔。这种蛋白质具有低水平的 FGly 生成活性，但可以与另一个家族成员异二聚化 - 一种具有高水平 FGly 生成活性的蛋白质。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by Enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]