2. Gene
  3. MYRIP - myosin VIIA and Rab interacting protein Gene

MYRIP - myosin VIIA and Rab interacting protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌球蛋白 VIIA 和 Rab 相互作用蛋白

种属: Homo sapiens

同用名: SLAC2C; SLAC2-C

基因 ID: 25924 | 基因类型: protein coding

关于 MYRIP

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:39,808,914-40,260,321 (from NCBI)

This gene has 10 transcripts (splice variants), 116 orthologues and 2 paralogues. Broad expression in brain (RPKM 7.4), spleen (RPKM 4.2) and 23 other tissues.

功能概要

预测启用肌动蛋白结合活性和肌球蛋白结合活性。预计参与胰岛素分泌的正调节。预计位于肌动蛋白细胞骨架；致密核心颗粒；和细胞质的核周区。预测是 exocyst 的一部分。预计在皮质肌动蛋白细胞骨架中具有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable actin binding activity and Myosin binding activity. Predicted to be involved in positive regulation of Insulin secretion. Predicted to be located in actin cytoskeleton; dense core granule; and perinuclear region of cytoplasm. Predicted to be part of exocyst. Predicted to be active in cortical actin Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

MYRIP 基因产物(5)

mRNA Protein Name
NM_001284423.2 NP_001271352.1 rab effector MyRIP isoform a
NM_001284424.2 NP_001271353.1 rab effector MyRIP isoform b
NM_001284425.2 NP_001271354.1 rab effector MyRIP isoform c
NM_001284426.2 NP_001271355.1 rab effector MyRIP isoform d
NM_015460.4 NP_056275.2 rab effector MyRIP isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11964381 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYRIP 蛋白结构

FYVE_2

FYVE_2: FYVE-type zinc finger (9 - 125)

Rab_eff_C

Rab_eff_C: Rab effector MyRIP/melanophilin C-terminus (152 - 859)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 859 a.a.
蛋白主名 其他名称

rab effector MyRIP

Slp homologue lacking C2 domains

MYRIP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MYRIP Q8NFW9 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
种属内
MYRIP Q8NFW9 OIP5 Homo sapiens O43482
Y2H Array
32296183
种属内
MYRIP Q8NFW9 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
种属内
MYRIP Q8NFW9 C1orf216 Homo sapiens Q8TAB5
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Deafness, Autosomal Dominant 50

DFNA50

Autosomal Dominant Nonsyndromic Deafness 50

Autosomal Dominant Deafness 50

Deafness, Autosomal Dominant, Type 50
Griscelli Syndrome

Chediak-Higashi-Like Syndrome

Griscelli-Prunieras Syndrome

Partial Albinism-Immunodeficiency Syndrome

Griscelli Disease

Gs

Hypopigmentation Immunodeficiency Disease

Partial Albinism With Immunodeficiency

Immunodeficiency Syndrome With Hypopigmentation

Hypopigmentation-Immunodeficiency Disease
Cerebrooculofacioskeletal Syndrome 1

Cofs Syndrome

COFS1

Pena-Shokeir Syndrome Type 2

Cofs

Pena-Shokeir Syndrome, Type Ii

Cerebrooculofacioskeletal Syndrome

Cerebro-Oculo-Facio-Skeletal Syndrome 1

Pena Shokeir Syndrome Type 2
Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome

Dystrophia Retinae Pigmentosa-Dysostosis Syndrome

Graefe-Usher Syndrome

Hallgren Syndrome

Usher'S Syndrome

Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa-Hearing Loss Syndrome

Ush

Usher Syndromes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08971 MYRIP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MYRIP MGD MGI:2384407
Felis catus MYRIP VGNC VGNC:102783
Bos taurus MYRIP VGNC VGNC:31846
Macaca mulatta MYRIP VGNC VGNC:74992
Rattus norvegicus MYRIP RGD RGD:727731
Canis familiaris MYRIP VGNC VGNC:43589
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