2. Gene
  3. TKFC - triokinase and FMN cyclase Gene

TKFC - triokinase and FMN cyclase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：三激酶和 FMN 环化酶

种属: Homo sapiens

同用名: DAK; NET45; TKFCD

基因 ID: 26007 | 基因类型: protein coding

关于 TKFC

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,333,228-61,353,426 (from NCBI)

This gene has 21 transcripts (splice variants), 191 orthologues and is associated with 3 phenotypes. Broad expression in duodenum (RPKM 30.4), small intestine (RPKM 22.4) and 23 other tissues.

功能概要

该基因是二羟基丙酮激酶家族的成员，其蛋白质结构不同于其他激酶。该基因的产物磷酸化二羟基丙酮，还催化 FAD 形成核黄素 4',5'-磷酸 (又名细胞周期蛋白 FMN) 。已发现该基因的几种可变剪接转录物变体。[RefSeq 提供，2017 年 6 月]

This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from Other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2017]

TKFC 基因产物(6)

mRNA Protein Name
NM_001351976.2 NP_001338905.1 triokinase/FMN cyclase isoform b
NM_001351977.2 NP_001338906.1 triokinase/FMN cyclase isoform a
NM_001351978.2 NP_001338907.1 triokinase/FMN cyclase isoform c
NM_001351979.2 NP_001338908.1 triokinase/FMN cyclase isoform d
NM_001351980.2 NP_001338909.1 triokinase/FMN cyclase isoform e
NM_015533.4 NP_056348.2 triokinase/FMN cyclase isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables FAD-AMP lyase (cyclizing) activity IDA
IDA: 通过直接分析推断
16289032 GOA
enables glycerone kinase activity IDA
IDA: 通过直接分析推断
4688871 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17600090 GOA
enables triokinase activity IDA
IDA: 通过直接分析推断
4688871 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in carbohydrate metabolic process IDA
IDA: 通过直接分析推断
4688871 GOA
involved in carbohydrate phosphorylation IDA
IDA: 通过直接分析推断
4688871 GOA
involved in negative regulation of MDA-5 signaling pathway IDA
IDA: 通过直接分析推断
17600090 GOA
involved in regulation of innate immune response IDA
IDA: 通过直接分析推断
16289032 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

triokinase/FMN cyclase

ATP-dependent dihydroxyacetone kinase

TKFC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TKFC Q3LXA3 SDCBP Homo sapiens O00560
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Triokinase And Fmn Cyclase Deficiency Syndrome

TKFCD
Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10

Cardiomyopathy And Cataract

Cataract And Cardiomyopathy

MTDPS10

Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome

Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10

Senger Syndrome
Inherited Metabolic Disorder

Inborn Errors Of Metabolism

Inborn Metabolic Disorder

Inborn Metabolism Disorder

Metabolic Hereditary Disorder

Inborn Error Of Metabolism

Metabolism, Inborn Errors
Squamous Cell Bile Duct Carcinoma

Bile Duct Squamous Cell Carcinoma
Lung Combined Type Small Cell Carcinoma

Combined Small Cell Carcinoma Of The Lung

Combined Type Small Cell Carcinoma Of Lung
Microcytic Anemia

Iron-Refractory Iron Deficiency Anemia
Fructosuria, Essential

Essential Fructosuria

Ketohexokinase Deficiency

Fructosuria

Hepatic Fructokinase Deficiency

Fructokinase Deficiency

FRUCT

Deficiency Of Fructokinase
Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14558 TKFC Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TKFC VGNC VGNC:66202
Canis familiaris TKFC VGNC VGNC:47390
Bos taurus TKFC VGNC VGNC:56287
Macaca mulatta TKFC VGNC VGNC:79441
Rattus norvegicus TKFC RGD RGD:1311026
Mus musculus TKFC MGD MGI:2385084
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