2. Gene
  3. SERBP1 - SERPINE1 mRNA binding protein 1 Gene

SERBP1 - SERPINE1 mRNA binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SERPINE1 mRNA 结合蛋白 1

种属: Homo sapiens

同用名: CGI-55; CHD3IP; HABP4L; PAIRBP1; PAI-RBP1

基因 ID: 26135 | 基因类型: protein coding

关于 SERBP1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:67,407,810-67,430,402 (from NCBI)

This gene has 8 transcripts (splice variants), 282 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 40.3), thyroid (RPKM 34.9) and 25 other tissues.

功能概要

启用 SUMO 绑定活动； mRNA 3'-UTR 结合活性；和核糖体结合活性。参与 PML 身体组织。位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Enables SUMO binding activity; mRNA 3'-UTR binding activity; and ribosome binding activity. Involved in PML body organization. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SERBP1 基因产物(4)

mRNA Protein Name
NM_001018067.2 NP_001018077.1 plasminogen activator inhibitor 1 RNA-binding protein isoform 1
NM_001018068.2 NP_001018078.1 plasminogen activator inhibitor 1 RNA-binding protein isoform 2
NM_001018069.2 NP_001018079.1 plasminogen activator inhibitor 1 RNA-binding protein isoform 3
NM_015640.4 NP_056455.3 plasminogen activator inhibitor 1 RNA-binding protein isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding EXP
EXP: 通过实验结果推断
34631798 GOA
enables SUMO binding IDA
IDA: 通过直接分析推断
28695742 GOA
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
11001948 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12505151 GOA
enables ribosome binding IDA
IDA: 通过直接分析推断
23636399 GOA
enables translation repressor activity IDA
IDA: 通过直接分析推断
36691768 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in PML body organization IDA
IDA: 通过直接分析推断
28695742 GOA
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
36691768 GOA
involved in ribosome hibernation IDA
IDA: 通过直接分析推断
36691768 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16879614 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16879614 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SERBP1 蛋白结构

HABP4_PAI-RBP1

HABP4_PAI-RBP1: Hyaluronan / mRNA binding family (189 - 314)

  • 0
  • 100
  • 200
  • 300
  • 408 a.a.
蛋白主名 其他名称

plasminogen activator inhibitor 1 RNA-binding protein

PAI-1 mRNA binding protein

SERBP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SERBP1 Q8NC51 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra SERBP1 Q8NC51 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra SERBP1 Q8NC51 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra SERBP1 Q8NC51 SERPINH1 Homo sapiens P50454
Validated Y2H
32814053
Intra SERBP1 Q8NC51 SERPINH1 Homo sapiens P50454
Y2H Array
32814053
Intra SERBP1 Q8NC51 SERPINH1 Homo sapiens P50454
Y2H Pooling
32814053
Intra SERBP1 Q8NC51 CHD3 Homo sapiens Q12873
Y2H
12505151
Intra SERBP1 Q8NC51 CHD3 Homo sapiens Q12873
Anti Bait CoIP
12505151
Intra SERBP1 Q8NC51 CHD3 Homo sapiens Q12873
Pull Down
12505151
Intra SERBP1 Q8NC51 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra SERBP1 Q8NC51 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra SERBP1 Q8NC51 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra SERBP1 Q8NC51 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra SERBP1 Q8NC51 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra SERBP1 Q8NC51 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12687 SERBP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SERBP1 VGNC VGNC:46018
Felis catus SERBP1 VGNC VGNC:65016
Bos taurus SERBP1 VGNC VGNC:34461
Mus musculus SERBP1 MGD MGI:1914120
Macaca mulatta SERBP1 VGNC VGNC:81566
Rattus norvegicus SERBP1 RGD RGD:619907
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