2. Gene
  3. GAPDHS - glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Gene

GAPDHS - glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：3-磷酸甘油醛脱氢酶，生精

种属: Homo sapiens

同用名: GAPD2; GAPDS; HSD-35; GAPDH-2; HEL-S-278

基因 ID: 26330 | 基因类型: protein coding

关于 GAPDHS

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,533,456-35,545,319 (from NCBI)

This gene has 3 transcripts (splice variants), 189 orthologues and 1 paralogue. Biased expression in testis (RPKM 87.7) and thyroid (RPKM 2.9).

功能概要

该基因编码的蛋白质属于甘油醛-3-磷酸脱氢酶家族，在碳水化合物代谢中起重要作用。与其体细胞对应物一样，这种精子特异性酶以烟酰胺腺嘌呤二核苷酸依赖性方式发挥作用，以去除氢并将磷酸添加到甘油醛 3-磷酸中以形成 1,3-二磷酸甘油酸。在精子发生过程中，这种酶可能在调节不同能量产生途径之间的转换中发挥重要作用，并且是精子活力和男性生育能力所必需的。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of Enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific Enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this Enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]

GAPDHS 基因产物(1)

mRNA Protein Name
NM_014364.5 NP_055179.1 glyceraldehyde-3-phosphate dehydrogenase, testis-specific
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16820410 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GAPDHS 蛋白结构

Gp_dh_N

Gp_dh_N: Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain (77 - 224)

Gp_dh_C

Gp_dh_C: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (229 - 386)

  • 0
  • 100
  • 200
  • 300
  • 408 a.a.
蛋白主名 其他名称

glyceraldehyde-3-phosphate dehydrogenase, testis-specific

epididymis secretory protein Li 278

关联疾病

疾病名称 别名
Ovarian Dysgenesis 2

Premature Ovarian Failure 4

ODG2

Ovarian Dysgenesis, Hypergonadotropic, X-Linked

Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis

Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis

X-Linked Hypergonadotropic Ovarian Dysgenesis

POF4

Dysgenesis, Ovarian, Type 2
Retinitis Pigmentosa 38

RP38

Rod-Cone Dystrophy, Childhood-Onset

Retinitis Pigmentosa, Type 38
Corneal Dystrophy And Perceptive Deafness

Corneal Dystrophy-Perceptive Deafness Syndrome

CDPD

Harboyan Syndrome

Cdpd1

Corneal Dystrophy And Sensorineural Deafness

Corneal Endothelial Dystrophy And Perceptive Deafness

Corneal Dystrophy With Progressive Deafness

Congenital Corneal Dystrophy, Progressive Sensorineural Deafness

Corneal Dystrophy With Progressive Hearing Loss

Corneal Dystrophy-Perceptive Hearing Loss Syndrome

Dystrophy, Corneal, Endothelial, And Perceptive Deafness
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-16361A Omigapil maleate Inhibitor 99.43% Phase 1
HY-147280 Misetionamide Inducer 99.49% Phase 1
Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-123962 G6PD activator AG1 Activator 99.54% 否
HY-112758 DLin-KC2-DMA 99.88% 否
HY-D0849 Sodium iodoacetate Inhibitor 99.91% 否
HY-120838 Heptelidic acid Inhibitor 97.50% 否
HY-157395 malonyl-NAC / 否
HY-132126 SPHINX Inhibitor 99.87% 否
HY-RS05273 GAPDH Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-123668 KM05382 Inhibitor / 否
HY-131921 DL-Glyceraldehyde 3-phosphate diethyl acetal barium / 否
HY-161668 Ru-Poma / 否
HY-N3247 Monomethyl kolavate Inhibitor / 否
HY-RS03616 DDIT4L Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05274 GAPDHS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS16258 Lipt1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus GAPDHS VGNC VGNC:29248
Macaca mulatta GAPDHS VGNC VGNC:72778
Mus musculus GAPDHS MGD MGI:95653
Rattus norvegicus GAPDHS RGD RGD:620150
Felis catus GAPDHS VGNC VGNC:62460
Canis familiaris GAPDHS VGNC VGNC:41109
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