2. Gene
  3. Map3k1 - mitogen-activated protein kinase kinase kinase 1 Gene

Map3k1 - mitogen-activated protein kinase kinase kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mekk; MEKK1; MAPKKK1

基因 ID: 26401 | 基因类型: protein coding

关于 Map3k1

功能概要

Enables JUN kinase kinase kinase activity; MAP kinase kinase activity; and cytoskeletal protein binding activity. Involved in positive regulation of JUN kinase activity. Acts upstream of or within several processes, including JNK cascade; eyelid development in camera-type eye; and positive regulation of actin filament polymerization. Part of filamentous actin. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6 and breast Cancer. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map3k1 基因产物(1)

mRNA Protein Name
NM_011945.3 NP_036075.2 mitogen-activated protein kinase kinase kinase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables JUN kinase kinase kinase activity IDA
IDA: 通过直接分析推断
14967141 MGI
enables MAP kinase kinase activity EXP
EXP: 通过实验结果推断
9065412 MGI
enables cytoskeletal protein binding IDA
IDA: 通过直接分析推断
25224220 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10523642 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within JNK cascade IDA
IDA: 通过直接分析推断
14967141 MGI
acts upstream of or within apoptotic mitochondrial changes IMP
IMP: 通过突变表型推断
15882989 MGI
acts upstream of or within camera-type eye development IMP
IMP: 通过突变表型推断
12941696 MGI
acts upstream of or within epithelial cell morphogenesis IMP
IMP: 通过突变表型推断
23201579 MGI
acts upstream of or within eyelid development in camera-type eye IMP
IMP: 通过突变表型推断
23201579 MGI
acts upstream of or within morphogenesis of an epithelial sheet IMP
IMP: 通过突变表型推断
25224220 MGI
involved in positive regulation of JUN kinase activity IDA
IDA: 通过直接分析推断
10523642 MGI
acts upstream of or within positive regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
12941696 MGI
acts upstream of or within regulation of cell migration IMP
IMP: 通过突变表型推断
12941696 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
12941696 MGI
acts upstream of or within wound healing IMP
IMP: 通过突变表型推断
12941696 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of filamentous actin IDA
IDA: 通过直接分析推断
25224220 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase 1

MAPK/ERK kinase kinase 1

MEK kinase 1

重组 Map3k1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700593 MAP3K1 Protein, Mouse (His) P53349 (Q1216-W1493) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136848 SM1-71 Inhibitor 96.09% 否
HY-RS08046 MAP3K1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Map3k1 NCBI NCBI:4214
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