Mapk8 - mitogen-activated protein kinase 8 Gene

中文名称：丝裂原活化蛋白激酶 8

种属: Mus musculus

同用名: JNK; JNK1; Prkm8; SAPK1

关于 Mapk8

功能概要

该基因编码的蛋白可启动 JUN 激酶活性和蛋白丝氨酸/苏氨酸/酪氨酸激酶活性。涉及几个进程，包括JNK级联；神经元的产生；细胞蛋白质代谢过程的正向调控。作用于多个过程的上游或内部，包括细胞对一氧化氮的反应；确定背部特征的正调节；和蛋白质磷酸化。位于几种细胞成分中，包括基底树突；线粒体；和足体。以多种结构表达，包括中枢神经系统；泌尿生殖系统；口腔上皮；感觉器官；和皮肤。该基因的人类直系同源物与腹主动脉瘤有关；慢性粘膜皮肤念珠菌病;结直肠腺瘤;直肠良性肿瘤;和 2 型糖尿病。与人 MAPK8（丝裂原活化蛋白激酶 8）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including JNK cascade; generation of neurons; and positive regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to nitric oxide; positive regulation of determination of dorsal identity; and protein phosphorylation. Located in several cellular components, including basal dendrite; mitochondrion; and podosome. Is expressed in several structures, including central nervous system; genitourinary system; oral region epithelium; sensory organ; and skin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Apr 2022]