PTPN18 - protein tyrosine phosphatase non-receptor type 18 Gene

中文名称：18 型蛋白酪氨酸磷酸酶非受体

种属: Homo sapiens

同用名: BDP1; PTP-HSCF

关于 PTPN18

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 含有一个 PEST 基序，常作为蛋白质-蛋白质相互作用域，可能与蛋白质胞内半衰期有关。这种蛋白质可以差异化去磷酸化在肿瘤组织中过度表达的自磷酸化酪氨酸激酶，并且它似乎可以调节 HER2，HER2 是受体酪氨酸激酶的表皮生长因子受体家族的成员。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 11 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of Receptor Tyrosine Kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]