2. Gene
  3. ADGRF1 - adhesion G protein-coupled receptor F1 Gene

ADGRF1 - adhesion G protein-coupled receptor F1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：粘附 G 蛋白偶联受体 F1

种属: Homo sapiens

同用名: PGR19; GPR110; KPG_012; hGPCR36

基因 ID: 266977 | 基因类型: protein coding

关于 ADGRF1

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:46,997,708-47,042,332 (from NCBI)

This gene has 13 transcripts (splice variants), 158 orthologues and 42 paralogues. Biased expression in urinary bladder (RPKM 9.0), kidney (RPKM 6.7) and 5 other tissues.

功能概要

预计可启用 G 蛋白偶联受体活性。预测参与 G 蛋白偶联受体信号通路。预计在多个进程的上游或内部起作用，包括内存；神经系统发育；和 CREB 转录因子活性的正调控。预测位于胞外区和质膜。预计是膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within several processes, including memory; nervous system development; and positive regulation of CREB transcription factor activity. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

ADGRF1 基因产物(2)

mRNA Protein Name
NM_025048.4 NP_079324.2 adhesion G-protein coupled receptor F1 isoform 2 precursor
NM_153840.4 NP_722582.2 adhesion G-protein coupled receptor F1 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
34110646 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADGRF1 蛋白结构

SEA

SEA: SEA domain (154 - 233)

GPS

GPS: GPCR proteolysis site, GPS, motif (531 - 573)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (584 - 834)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 910 a.a.
蛋白主名 其他名称

adhesion G-protein coupled receptor F1

G protein-coupled receptor 110

ADGRF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ADGRF1 Q5T601 GNAQ Homo sapiens P50148
Anti Bait CoIP
34110646
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Usher Syndrome, Type Iic

Usher Syndrome Type 2c

USH2C

Usher Syndrome, Type 2c

Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic

Usher Syndrome Type Iic

Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic

Usher Syndrome 2c

Usher'S Syndrome Type 2c

Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic
Adie Pupil

Adie Syndrome

Holmes-Adie Syndrome

Poorly Reacting Pupils

Adie'S Pupil Or Syndrome

Adie'S Pupil Syndrome

Adie'S Syndrome

Adie'S Pupil

Has

Tonic, Sluggishly Reacting Pupil And Hypoactive Or Absent Tendon Reflexes

Tonic Pupil-Tendon Areflexia Syndrome

ADIEP

Tonic Pupil
Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect
Vibratory Urticaria

Vibratory Angioedema

Dermodistortive Urticaria

VBU

Ddu

Angioedema, Vibratory
Usher Syndrome Type 2

Ush2

Usher Syndrome Type Ii
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00352 ADGRF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ADGRF1 VGNC VGNC:59631
Macaca mulatta ADGRF1 VGNC VGNC:81007
Bos taurus ADGRF1 VGNC VGNC:25661
Canis familiaris ADGRF1 VGNC VGNC:37638
Rattus norvegicus ADGRF1 RGD RGD:1310285
Mus musculus ADGRF1 MGD MGI:1924846
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