1. Gene
  2. FETUB - fetuin B Gene

FETUB - fetuin B Gene

中文名称:胎球蛋白 B

种属: Homo sapiens

同用名: 16G2; Gugu; IRL685

基因 ID: 26998 | 基因类型: protein coding

关于 FETUB

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,635,969-186,653,141 (from NCBI)

This gene has 8 transcripts (splice variants), 268 orthologues and 3 paralogues. Restricted expression toward liver (RPKM 42.7).

功能概要

该基因编码的蛋白质是胎球蛋白家族的成员,是半胱氨酸蛋白酶抑制剂胱抑素超家族的一部分。胎球蛋白涉及多种不同的功能,包括成骨和骨吸收、胰岛素和肝细胞生长因子受体的调节以及对全身炎症的反应。这种蛋白质可能由细胞分泌。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine Protease Inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the Insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]

FETUB 基因产物(9)

mRNA Protein Name
NM_001308077.4 NP_001295006.1 fetuin-B isoform 2 precursor
NM_001308079.4 NP_001295008.1 fetuin-B isoform 3 precursor
NM_001375587.2 NP_001362516.1 fetuin-B isoform 1 precursor
NM_001375588.2 NP_001362517.1 fetuin-B isoform 5
NM_001375589.2 NP_001362518.1 fetuin-B isoform 6
NM_001375590.2 NP_001362519.1 fetuin-B isoform 6
NM_001375591.2 NP_001362520.1 fetuin-B isoform 6
NM_001375592.2 NP_001362521.1 fetuin-B isoform 6
NM_014375.3 NP_055190.2 fetuin-B isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FETUB 蛋白结构

Cystatin

Cystatin: Cystatin domain (37 - 120)

Cystatin

Cystatin: Cystatin domain (158 - 246)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
蛋白主名 其他名称

fetuin-B

fetuin-like protein IRL685

FETUB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FETUB Q9UGM5 HSD17B13 Homo sapiens Q7Z5P4 32296183
种属内
FETUB Q9UGM5 HSD17B13 Homo sapiens Q7Z5P4 32296183
种属内
FETUB Q9UGM5 EBP Homo sapiens Q15125 32296183
种属内
FETUB Q9UGM5 EBP Homo sapiens Q15125 32296183
种属内
FETUB Q9UGM5 DARS2 Homo sapiens Q6PI48 32296183
种属内
FETUB Q9UGM5 DARS2 Homo sapiens Q6PI48 32296183
种属内
FETUB Q9UGM5 MTIF3 Homo sapiens Q9H2K0 32296183
种属内
FETUB Q9UGM5 MTIF3 Homo sapiens Q9H2K0 32296183
种属内
FETUB Q9UGM5 CREB3L1 Homo sapiens Q96BA8 32296183
种属内
FETUB Q9UGM5 CREB3L1 Homo sapiens Q96BA8 32296183
种属内
FETUB Q9UGM5 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
FETUB Q9UGM5 ERGIC3 Homo sapiens Q9Y282 32296183
种属内
FETUB Q9UGM5 ERGIC3 Homo sapiens Q9Y282 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FETUB 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70930 Fetuin B Protein, Human (HEK293, His) Q9UGM5-1 (C16-P382) ≥95%

关联疾病

疾病名称 别名
Encephalitozoonosis

Infection By Encephalitozoon

Caffey Disease

Infantile Cortical Hyperostosis

CAFYD

Cortical Congenital Hyperostosis

Caffey-Silverman Syndrome

De Toni-Caffey Disease

Hyperostosis Cortical Infantile

Hyperostosis, Cortical, Congenital

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris FETUB VGNC VGNC:40826
Rattus norvegicus FETUB RGD RGD:69293
Felis catus FETUB VGNC VGNC:62233
Mus musculus FETUB MGD MGI:1890221
Bos taurus FETUB VGNC VGNC:28955
Macaca mulatta FETUB VGNC VGNC:72638
Others FETUB NCBI