ANKRD1 - ankyrin repeat domain 1 Gene

中文名称：锚蛋白重复结构域 1

种属: Homo sapiens

同用名: ALRP; CARP; C-193; CVARP; MCARP; bA320F15.2

基因 ID: 27063 | 基因类型: protein coding

关于 ANKRD1

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:90,912,096-90,921,087 (from NCBI)

This gene has 1 transcript (splice variant), 243 orthologues, 1 paralogue and is associated with 1 phenotype. Restricted expression toward heart (RPKM 2170.6).

功能概要

由该基因编码的蛋白质定位于内皮细胞的细胞核，并由 IL-1 和 TNF-α 刺激诱导。对大鼠心肌细胞的研究表明，该基因起着转录因子的作用。这种蛋白质与肌节蛋白肌钯蛋白和肌联蛋白之间的相互作用表明它也可能参与肌原纤维牵张传感器系统。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. [provided by RefSeq, Jul 2008]

ANKRD1 基因产物(1)

mRNA	Protein	Name
NM_014391.3	NP_055206.2	ankyrin repeat domain-containing protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	7730328	GOA
enables R-SMAD binding	IPI IPI: 通过物理相互作用推断	20599664	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	20599664	GOA
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	20599664	GOA
enables p53 binding	IPI IPI: 通过物理相互作用推断	20599664	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11309420	GOA
enables titin binding	IPI IPI: 通过物理相互作用推断	14583192	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	20599664	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cardiac muscle tissue morphogenesis	IMP IMP: 通过突变表型推断	19525294	GOA
involved in cellular response to interleukin-1	IDA IDA: 通过直接分析推断	7730328	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: 通过直接分析推断	7730328	GOA
involved in cellular response to mechanical stimulus	IDA IDA: 通过直接分析推断	17239933	GOA
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: 通过直接分析推断	11139470	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: 通过直接分析推断	7730328	GOA
involved in negative regulation of DNA biosynthetic process	IMP IMP: 通过突变表型推断	11139470	GOA
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator	IDA IDA: 通过直接分析推断	20599664	GOA
involved in positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	15805281	GOA
involved in positive regulation of protein secretion	IMP IMP: 通过突变表型推断	17239933	GOA
involved in response to muscle stretch	IMP IMP: 通过突变表型推断	19608030	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	12054667	GOA
located in cytosol	IDA IDA: 通过直接分析推断	19608030	GOA
located in nucleus	IDA IDA: 通过直接分析推断	7730328	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANKRD1 蛋白结构

Ank_2

0
100
200
300
319 a.a.

蛋白主名

其他名称

ankyrin repeat domain-containing protein 1

ankyrin repeat domain 1 (cardiac muscle)

ANKRD1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ANKRD1	Q15327	NAGK	Homo sapiens	Q9UJ70-2	Validated Y2H	32296183
Intra	ANKRD1	Q15327	NAGK	Homo sapiens	Q9UJ70-2	Y2H Array	32296183
Intra	ANKRD1	Q15327	NAGK	Homo sapiens	Q9UJ70-2	Y2H Prey Pooling	32296183
Intra	ANKRD1	Q15327	SPANXN2	Homo sapiens	Q5MJ10	Validated Y2H	32296183
Intra	ANKRD1	Q15327	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ANKRD1	Q15327	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	ANKRD1	Q15327	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ANKRD1	Q15327	CDCA7L	Homo sapiens	Q96GN5	Validated Y2H	32296183
Intra	ANKRD1	Q15327	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	32296183
Intra	ANKRD1	Q15327	ZNF446	Homo sapiens	Q9NWS9-2	Y2H Prey Pooling	32296183
Intra	ANKRD1	Q15327	ZNF446	Homo sapiens	Q9NWS9-2	Validated Y2H	32296183
Intra	ANKRD1	Q15327	ZNF446	Homo sapiens	Q9NWS9-2	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Total Anomalous Pulmonary Venous Return 1

Scimitar Syndrome	Total Anomalous Pulmonary Venous Return
Anomalous Pulmonary Venous Return	Scimitar Anomaly
TAPVR1	Apvr
Halasz Syndrome	Hypogenetic Lung Syndrome
Pulmonary Venolobar Syndrome	TAPVR
Congenital Total Pulmonary Venous Return Anomaly	Congenital Venolobar Syndrome
Mirror-Image Lung Syndrome	Vena Cava Bronchovascular Syndrome
Pulmonary Venous Return Anomaly	Congenital Pulmonary Venolobar Syndrome
Epibronchial Right Pulmonary Vein Syndrome

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Sciatic Neuropathy

Lesion Of Sciatic Nerve

Nerve Lesion Sciatic

Sciatic Neuropathy

Mononeuritis Of Lower Limb

Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy	Cardiomyopathy, Restrictive
Cardiomyopathy, Constrictive	Primary Restrictive Cardiomyopathy
Rcm	Cardiomyopathy Restrictive

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00712	ANKRD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ANKRD1	RGD	RGD:61989
Bos taurus	ANKRD1	VGNC	VGNC:25908
Canis familiaris	ANKRD1	VGNC	VGNC:37880
Macaca mulatta	ANKRD1	VGNC	VGNC:69616
Mus musculus	ANKRD1	MGD	MGI:1097717
Felis catus	ANKRD1	VGNC	VGNC:97350

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4