DKK4 - dickkopf WNT signaling pathway inhibitor 4 Gene

中文名称：dickkopf WNT 信号通路抑制因子 4

种属: Homo sapiens

同用名: DKK-4

基因 ID: 27121 | 基因类型: protein coding

关于 DKK4

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,374,063-42,391,322 (from NCBI)

This gene has 1 transcript (splice variant) and 109 orthologues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是 dickkopf 家族的一员。分泌的蛋白质包含两个富含半胱氨酸的区域，并通过与 Wnt 信号通路的相互作用参与胚胎发育。这种蛋白质的活性通过与 Wnt 辅助受体和辅助因子 kremen 2 的结合来调节。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]

DKK4 基因产物(1)

mRNA	Protein	Name
NM_014420.3	NP_055235.1	dickkopf-related protein 4 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DKK4 蛋白结构

Dickkopf_N

Prokineticin

0
100
200
224 a.a.

蛋白主名

其他名称

dickkopf-related protein 4

dickkopf-4

DKK4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	DKK4	Q9UBT3	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	DKK4	Q9UBT3	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	DKK4	Q9UBT3	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Bone Disease

Bone Diseases	Skeletal Disease
Skeletal Disorder	Disorder Of Skeletal System

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03790	DKK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	DKK4	VGNC	VGNC:28082
Felis catus	DKK4	VGNC	VGNC:78481
Rattus norvegicus	DKK4	RGD	RGD:1563172
Canis familiaris	DKK4	VGNC	VGNC:39972
Macaca mulatta	DKK4	VGNC	VGNC:71805
Mus musculus	DKK4	MGD	MGI:2385299

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DKK4 - dickkopf WNT signaling pathway inhibitor 4 Gene

关于 DKK4

功能概要

DKK4 基因产物(1)

DKK4 蛋白结构

DKK4 蛋白互作信息

关联疾病

直系同源

热门区域

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DKK4 - dickkopf WNT signaling pathway inhibitor 4 Gene

关于 DKK4

功能概要

DKK4 基因产物(1)

DKK4 蛋白结构

DKK4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z