SLC39A1 - solute carrier family 39 member 1 Gene

中文名称：溶质载体家族 39 成员 1

种属: Homo sapiens

同用名: ZIP1; ZIRTL

基因 ID: 27173 | 基因类型: protein coding

关于 SLC39A1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,959,110-153,968,184 (from NCBI)

This gene has 10 transcripts (splice variants), 190 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 41.2), lung (RPKM 24.3) and 25 other tissues.

功能概要

该基因编码锌铁通透酶家族的一个成员。编码的蛋白质定位于细胞膜并充当锌摄取转运蛋白。该基因与前列腺癌、乳腺癌和阿尔茨海默病有关。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 12 月]

This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate Cancer, breast Cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

SLC39A1 基因产物(6)

mRNA	Protein	Name
NM_001271957.2	NP_001258886.1	zinc transporter ZIP1 isoform a
NM_001271958.2	NP_001258887.1	zinc transporter ZIP1 isoform a
NM_001271959.2	NP_001258888.1	zinc transporter ZIP1 isoform a
NM_001271960.2	NP_001258889.1	zinc transporter ZIP1 isoform a
NM_001271961.2	NP_001258890.1	zinc transporter ZIP1 isoform b
NM_014437.5	NP_055252.2	zinc transporter ZIP1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA
enables zinc ion transmembrane transporter activity	IDA IDA: 通过直接分析推断	11301334	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in zinc ion transmembrane transport	IDA IDA: 通过直接分析推断	11301334	GOA
involved in zinc ion transmembrane transport	IMP IMP: 通过突变表型推断	11301334	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	11301334	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC39A1 蛋白结构

Zip

0
100
200
300
324 a.a.

蛋白主名

其他名称

zinc transporter ZIP1

ZRT/IRT-like protein 1

SLC39A1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLC39A1	Q9NY26	NME2P1	Homo sapiens	O60361	Anti Tag CoIP	33961781
种属内	SLC39A1	Q9NY26	NME2P1	Homo sapiens	O60361	Anti Tag CoIP	28514442
种属内	SLC39A1	Q9NY26	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
种属内	SLC39A1	Q9NY26	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
种属内	SLC39A1	Q9NY26	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica	AEZ
Enteropathica	Brandt Syndrome
Ae	Acrodermatitis Enteropathica Zinc Deficiency Type
Danbolt-Cross Syndrome	Acrodermatitis Enteropathica, Zinc Deficiency Type
Inherited Zinc Deficiency	Acrodermatitis Enteropathica, Zinc Deficiency
Danbolt-Closs Syndrome	Primary Zinc Malabsorption Syndrome

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16233	Slc39a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS13228	SLC39A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SLC39A1	RGD	RGD:1305241
Felis catus	SLC39A1	VGNC	VGNC:65353
Macaca mulatta	SLC39A1	VGNC	VGNC:100141
Canis familiaris	SLC39A1	VGNC	VGNC:46400
Bos taurus	SLC39A1	VGNC	VGNC:34857
Mus musculus	SLC39A1	MGD	MGI:1353474

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC39A1 - solute carrier family 39 member 1 Gene

关于 SLC39A1

功能概要

SLC39A1 基因产物(6)

SLC39A1 蛋白结构

SLC39A1 蛋白互作信息

关联疾病

直系同源

热门区域

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SLC39A1 - solute carrier family 39 member 1 Gene

关于 SLC39A1

功能概要

SLC39A1 基因产物(6)

SLC39A1 蛋白结构

SLC39A1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z