2. Gene
  3. GOLGA4 - golgin A4 Gene

GOLGA4 - golgin A4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：高金 A4

种属: Homo sapiens

同用名: GCP2; GOLG; p230; CRPF46; MU-RMS-40.18

基因 ID: 2803 | 基因类型: protein coding

关于 GOLGA4

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:37,243,271-37,366,879 (from NCBI)

This gene has 14 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in thyroid (RPKM 27.2), testis (RPKM 25.9) and 25 other tissues.

功能概要

参与分泌途径中蛋白质和脂质的糖基化和转运的高尔基体由一系列堆叠的池 (扁平膜囊) 组成。高尔基体和微管之间的相互作用被认为对于高尔基体在有丝分裂过程中断裂后的重组很重要。该基因编码一种 golgins，这是一个定位于高尔基体的蛋白质家族。据推测，该蛋白质在高尔基体中 Rab6 调节的膜束缚事件中发挥作用。已在该基因中鉴定出编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2010 年 2 月]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

GOLGA4 基因产物(3)

mRNA Protein Name
NM_001172713.2 NP_001166184.1 golgin subfamily A member 4 isoform 1
NM_001410721.1 NP_001397650.1 golgin subfamily A member 4 isoform 3
NM_002078.5 NP_002069.2 golgin subfamily A member 4 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase binding IPI
IPI: 通过物理相互作用推断
14580338 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15265687 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi to plasma membrane protein transport IDA
IDA: 通过直接分析推断
15265687 GOA
involved in Golgi to plasma membrane protein transport IMP
IMP: 通过突变表型推断
22705394 GOA
involved in positive regulation of axon extension IDA
IDA: 通过直接分析推断
22705394 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
15265687 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15265687 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GOLGA4 蛋白结构

GRIP

GRIP: GRIP domain (2171 - 2213)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2230 a.a.
蛋白主名 其他名称

golgin subfamily A member 4

256 kDa golgin

GOLGA4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GOLGA4 Q13439 EXOC1 Homo sapiens Q9NV70
Y2H
17043677
种属内
GOLGA4 Q13439 LIMD1 Homo sapiens Q9UGP4
Anti Tag CoIP
33961781
种属内
GOLGA4 Q13439 ANKRD27 Homo sapiens Q96NW4
Anti Tag CoIP
22705394
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chronic Neutrophilic Leukemia

Cnl

Leukemia Neutrophilic Chronic
Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer

Hereditary Nonpolyposis Colorectal Cancer

Hereditary Nonpolyposis Colorectal Carcinoma

Hereditary Nonpolyposis Colorectal Neoplasms

Familial Nonpolyposis Colon Cancer

Hnpcc

Coca 1

Hereditary Defective Mismatch Repair Syndrome

Hereditary Non-Polyposis Colon Cancer

Hereditary Non-Polyposis Colon Cancer Syndrome

Hereditary Non-Polyposis Colorectal Cancer

Hereditary Non-Polyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colon Cancer Syndrome

Hereditary Nonpolyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colorectal Neoplasm

Hnpcc - Hereditary Nonpolyposis Colon Cancer

Cancer Family Syndrome

Familial Nonpolyposis Colorectal Cancer

Colon Cancer, Familial Nonpolyposis

Colorectal Neoplasms, Hereditary Nonpolyposis

Cancer, Colorectal, Nonpolyposis, Hereditary

Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Alzheimer Disease 14

AD14

Alzheimer'S Disease 14

Alzheimer Disease-14

Alzheimer'S Disease 14, Late Onset
Glycogen Storage Disease Ixa

Glycogen Storage Disease Type 9a

Glycogen Storage Disease Type Ixa

Glycogenosis Type 9a

Glycogenosis Type Ixa

Gsd Type 9a

Gsd Type Ixa

Gsd9a
Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2

Pontocerebellar Hypoplasia Type 2e

Pch2

PCH2E

Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy

Pontocerebellar Hypoplasia 2e

Pcca2

Progressive Cerebello-Cerebral Atrophy Type 2

Doid:0112328

Hypoplasia, Pontocerebellar, Type 2e

Pontocerebellar Hypoplasia, Type 2d

Pontocerebellar Hypoplasia Type 2a
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05585 GOLGA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GOLGA4 MGD MGI:1859646
Bos taurus GOLGA4 VGNC VGNC:29485
Rattus norvegicus GOLGA4 RGD RGD:1591925
Canis familiaris GOLGA4 VGNC VGNC:41340
Felis catus GOLGA4 VGNC VGNC:62639
Macaca mulatta GOLGA4 VGNC VGNC:73107
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