2. Gene
  3. GPR3 - G protein-coupled receptor 3 Gene

GPR3 - G protein-coupled receptor 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 3

种属: Homo sapiens

同用名: ACCA

基因 ID: 2827 | 基因类型: protein coding

关于 GPR3

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,392,622-27,395,814 (from NCBI)

This gene has 1 transcript (splice variant), 183 orthologues and 18 paralogues. Broad expression in brain (RPKM 2.0), thyroid (RPKM 0.6) and 17 other tissues.

功能概要

该基因是 G 蛋白偶联受体家族的成员，存在于细胞膜中。 G 蛋白偶联受体以七个跨膜结构域基序为特征，参与将外部信号转化为 G 蛋白介导的细胞内效应。编码的蛋白质在小鼠模型中激活腺苷酸环化酶并调节淀粉样蛋白-β 的产生，表明它可能在阿尔茨海默病中发挥作用。[RefSeq 提供，2012 年 10 月]

This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates Adenylate Cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]

GPR3 基因产物(1)

mRNA Protein Name
NM_005281.4 NP_005272.1 G-protein coupled receptor 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24069330 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPR3 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (57 - 297)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
蛋白主名 其他名称

G-protein coupled receptor 3

ACCA orphan receptor

GPR3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GPR3 P46089 APP Homo sapiens P05067-4
Anti Tag CoIP
24069330
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2

Acromegaly Due To Pituitary Adenoma 2

Acromegaly, X-Linked

Growth Hormone Secreting Pituitary Adenoma 2

Pituitary Adenoma, Growth Hormone-Secreting, 2

Pituitary Adenoma 2, Gh-Secreting

Gh-Secreting Pituitary Adenoma 2

X-Linked Acromegaly

Adenoma, Pituitary, Growth Hormone-Secreting, Type 2
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Lennox-Gastaut Syndrome

Lennox Syndrome

Encephalopathy Of Childhood

Epileptic Encephalopathy Lennox-Gastaut Type

Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

Lgs
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-108496 Sphingosine-1-phosphate Agonist ≥99.0% Phase 1
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12664 AF64394 Antagonist 98.01% 否
HY-155318A GPR3 agonist-2 Agonist 98.80% 否
HY-108496S Sphingosine-1-phosphate-d7 Agonist 99.00% 否
HY-RS05700 GPR3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GPR3 RGD RGD:628686
Mus musculus GPR3 MGD MGI:101908
Bos taurus GPR3 VGNC VGNC:29581
Canis familiaris GPR3 VGNC VGNC:41429
Macaca mulatta GPR3 VGNC VGNC:73131
Felis catus GPR3 VGNC VGNC:67423
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