2. Gene
  3. GPR4 - G protein-coupled receptor 4 Gene

GPR4 - G protein-coupled receptor 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 4

种属: Homo sapiens

同用名: GPR6C.l

基因 ID: 2828 | 基因类型: protein coding

关于 GPR4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,589,764-45,602,212 (from NCBI)

This gene has 2 transcripts (splice variants), 141 orthologues and 16 paralogues. Broad expression in fat (RPKM 4.0), lung (RPKM 2.3) and 22 other tissues.

功能概要

启用 G 蛋白偶联受体活性。参与多个过程，包括 G 蛋白偶联受体信号通路； Rho 蛋白信号转导的正调控；和对酸性 pH 值的反应。位于质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of Rho protein signal transduction; and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR4 基因产物(1)

mRNA Protein Name
NM_005282.3 NP_005273.1 G-protein coupled receptor 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IMP
IMP: 通过突变表型推断
20211729 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
17462861 GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
12955148 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
20211729 GOA
involved in positive regulation of Rho protein signal transduction IDA
IDA: 通过直接分析推断
17462861 GOA
involved in positive regulation of Rho protein signal transduction IMP
IMP: 通过突变表型推断
20211729 GOA
involved in regulation of cell adhesion IDA
IDA: 通过直接分析推断
22110680 GOA
involved in response to acidic pH IDA
IDA: 通过直接分析推断
17462861 GOA
involved in response to acidic pH IMP
IMP: 通过突变表型推断
12955148 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
20211729 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPR4 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (35 - 286)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
蛋白主名 其他名称

G-protein coupled receptor 4

G-protein coupled receptor 19

G-protein coupled receptor 6C.l

关联疾病

疾病名称 别名
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Congenital Central Hypoventilation Syndrome

Cchs

Haddad Syndrome

Ondine Curse

Ondine Syndrome

Congenital Central Hypoventilation

Congenital Central Alveolar Hypoventilation Syndrome

Congenital Failure Of Autonomic Control

Ondine'S Curse

Primary Alveolar Hypoventilation

Ondine-Hirschsprung Disease

Central Congenital Hypoventilation Syndrome

Congenital Ondine Curse

Idiopathic Congenital Central Alveolar Hypoventilation

Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome

Ondine-Hirschsprung Syndrome
Prolactin Producing Pituitary Tumor

Prolactin-Producing Pituitary Gland Carcinoma

Prolactin-Producing Pituitary Tumor

Malignant Prolactin Producing Neoplasm Of Pituitary Gland

Malignant Prolactinoma

Prolactin Producing Pituitary Tumour

Prolactin Secreting Tumor Of Pituitary

Prolactin Secreting Tumour Of Pituitary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101784 NE 52-QQ57 99.89% 否
HY-101536 GPR4 antagonist 1 Antagonist 98.92% 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GPR4 VGNC VGNC:67427
Macaca mulatta GPR4 VGNC VGNC:73136
Canis familiaris GPR4 VGNC VGNC:41435
Rattus norvegicus GPR4 RGD RGD:1311604
Mus musculus GPR4 MGD MGI:2441992
Bos taurus GPR4 VGNC VGNC:29587
Others GPR4 NCBI
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