2. Gene
  3. GPR17 - G protein-coupled receptor 17 Gene

GPR17 - G protein-coupled receptor 17 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 17

种属: Homo sapiens

基因 ID: 2840 | 基因类型: protein coding

关于 GPR17

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,646,153-127,652,639 (from NCBI)

This gene has 6 transcripts (splice variants), 189 orthologues and 16 paralogues. Biased expression in brain (RPKM 16.2), endometrium (RPKM 2.8) and 5 other tissues.

功能概要

预计可启用 G 蛋白偶联受体活性。预计参与磷脂酶 C 激活 G 蛋白偶联信号通路中 Rho 蛋白信号转导的正向调节和胞质钙离子浓度的正向调节。预计在对抗原刺激的炎症反应的负调节上游或负调节中起作用。预测位于质膜中。预计是质膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within negative regulation of inflammatory response to antigenic stimulus. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR17 基因产物(4)

mRNA Protein Name
NM_001161415.2 NP_001154887.1 uracil nucleotide/cysteinyl leukotriene receptor isoform a
NM_001161416.2 NP_001154888.1 uracil nucleotide/cysteinyl leukotriene receptor isoform b
NM_001161417.2 NP_001154889.1 uracil nucleotide/cysteinyl leukotriene receptor isoform b
NM_005291.3 NP_005282.1 uracil nucleotide/cysteinyl leukotriene receptor isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
36613703 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPR17 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (76 - 325)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
蛋白主名 其他名称

uracil nucleotide/cysteinyl leukotriene receptor

P2Y-like receptor

关联疾病

疾病名称 别名
Strabismic Amblyopia

Suppression Amblyopia

Amblyopia

Amblyopia, Suppression
Persistent Mild Asthma
Periventricular Leukomalacia

Leukomalacia, Periventricular

Pvl

Leukomalacia Periventricular
Encephalomalacia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-19638A Cangrelor tetrasodium Antagonist 99.92% 否
HY-19638 Cangrelor Antagonist / 否
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-146486 P2Y2R/GPR17 antagonist 1 Inhibitor 98.85% 否
HY-111323 ASN06917370 99.23% 否
HY-128111 ASN02563583 Activator 99.21% 否
HY-113667 ASN04885796 Activator 99.61% 否
HY-128128 ASN04421891 Modulator 99.00% 否
HY-164311 GPR17 modulator-1 Modulator / 否
HY-170589 GPR17 antagonist 1 Antagonist / 否
HY-RS05679 GPR17 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-159920 PSB-22269 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus GPR17 VGNC VGNC:29568
Macaca mulatta GPR17 VGNC VGNC:73126
Mus musculus GPR17 MGD MGI:3584514
Canis familiaris GPR17 VGNC VGNC:41414
Rattus norvegicus GPR17 RGD RGD:1589785
Felis catus GPR17 VGNC VGNC:67417
Others GPR17 NCBI
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