2. Gene
  3. MCHR1 - melanin concentrating hormone receptor 1 Gene

MCHR1 - melanin concentrating hormone receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：黑色素浓缩激素受体 1

种属: Homo sapiens

同用名: SLC1; GPR24; MCH1R; SLC-1; MCH-1R

基因 ID: 2847 | 基因类型: protein coding

关于 MCHR1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:40,679,484-40,682,812 (from NCBI)

This gene has 4 transcripts (splice variants), 241 orthologues and 33 paralogues. Biased expression in brain (RPKM 4.7), ovary (RPKM 1.2) and 5 other tissues.

功能概要

由该基因编码的蛋白质是 G 蛋白偶联受体家族 1 的成员，是一种结合黑色素浓缩激素的完整质膜蛋白。编码的蛋白质可以抑制 cAMP 积累并刺激细胞内钙流动，并且可能参与食物消耗的神经元调节。尽管在结构上与生长抑素受体相似，但这种蛋白质似乎不与生长抑素结合。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]

MCHR1 基因产物(1)

mRNA Protein Name
NM_005297.4 NP_005288.4 melanin-concentrating hormone receptor 1
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cilium IDA
IDA: 通过直接分析推断
28154160 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MCHR1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (126 - 380)

  • 0
  • 100
  • 200
  • 300
  • 422 a.a.
蛋白主名 其他名称

melanin-concentrating hormone receptor 1

G protein-coupled receptor 24

MCH receptor 1

somatostatin receptor-like protein

关联疾病

疾病名称 别名
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency

LEPD

Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency

Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction

Leptin
Meckel Syndrome, Type 1

Meckel Syndrome

Meckel-Gruber Syndrome

Dysencephalia Splanchnocystica

Meckel Syndrome 1

MKS1

Mks

Gruber Syndrome

Meckel-Gruber Syndrome, Type 1

Mes

Dysencephalia Splachnocystica

Meckel Gruber Syndrome

Meckel Syndrome Type 1
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1

Vitiligo

VAMAS1

Slev1

Vtlg

Systemic Lupus Erythematosus, Vitiligo-Related

Vitiligo-Associated Multiple Autoimmune Disease 1

Systemic Lupus Erythematosus Vitiligo-Related
Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Iminoglycinuria

Iminoglycinuria, Digenic

IG
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-U00257 AZD1979 Antagonist 98.09% Phase 1
Pre-clinical Phase
生物活性分子 (19)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107625A SNAP 94847 hydrochloride Inhibitor 99.90% 否
HY-100321 MCHR1 antagonist 2 98.27% 否
HY-P1204 [Ala17]-MCH Agonist 98.28% 否
HY-101699 AMG-076 free base Antagonist / 否
HY-107625 SNAP 94847 Antagonist / 否
HY-107626 ATC0065 Antagonist / 否
HY-107626A ATC0065 free base Antagonist / 否
HY-116031 ATC0175 free base Antagonist / 否
HY-120608 BMS-814580 Inhibitor / 否
HY-136152 MCHR1 antagonist 3 Antagonist / 否
HY-161899 MCHR1 antagonist 4 Antagonist / 否
HY-P1204A [Ala17]-MCH TFA Agonist / 否
HY-RS08225 MCHR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08226 Mchr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08227 Mchr1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-101699A AMG-076 Antagonist / 否
HY-12433 BMS-819881 / 否
HY-100318 NGD-4715 Antagonist / 否
HY-U00353 MCHR1 antagonist 1 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MCHR1 VGNC VGNC:95360
Mus musculus MCHR1 MGD MGI:2180756
Felis catus MCHR1 VGNC VGNC:67422
Rattus norvegicus MCHR1 RGD RGD:619841
Canis familiaris MCHR1 VGNC VGNC:43076
Bos taurus MCHR1 VGNC VGNC:31305
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