2. GPCR/G Protein Neuronal Signaling
  3. MCHR1 (GPR24)
  4. ATC0175 free base

ATC0175 (free base) 是一种强效且选择性的黑色素浓缩激素受体 1 (MCH-R1) 拮抗剂，IC50 值为 3.4 nM，同时对 Y5 和 α2A receptors 具有良好的选择性。ATC0175 (free base) 有望用于肥胖方面的研究。

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ATC0175 free base Chemical Structure

ATC0175 free base Chemical Structure

CAS No. : 509118-03-0

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ATC0175 free base 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATC0175 (free base) is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH-R1) with an IC50 value of 3.4 nM, as well as good selectivity over the Y5 and the α2A receptors. ATC0175 (free base) is promising for research of obesity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
8.28 nM
Compound: ATC-0175
Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay
Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay
[PMID: 31678007]
COS-1 IC50
260 nM
Compound: 28 (ATC-O175)
Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells
Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cells
[PMID: 16002290]
COS-1 IC50
2700 nM
Compound: 28 (ATC-O175)
Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cells
Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cells
[PMID: 16002290]
HEK293 IC50
3.4 nM
Compound: 28 (ATC-O175)
Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HEK293 cells
Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HEK293 cells
[PMID: 16002290]
HEK293 IC50
7.2 nM
Compound: ATC-0175
Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay
Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay
[PMID: 19773162]
分子量

425.47

Formula

C23H25F2N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATC0175 free base 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATC0175509118-03-0ATC 0175ATC-0175MCHR1 (GPR24)Melanin concentrating hormone receptor 1MCH-R1Y5α2A receptorsobesityInhibitorinhibitorinhibit

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