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  2. EPHA6 - EPH receptor A6 Gene

EPHA6 - EPH receptor A6 Gene

中文名称:EPH 受体 A6

种属: Homo sapiens

同用名: EHK2; EK12; EPA6; EHK-2; HEK12; PRO57066

基因 ID: 285220 | 基因类型: protein coding

关于 EPHA6

Cytogenetic location: 3q11.2 Genomic coordinates (GRCh38): 3:96,814,594-97,761,532 (from NCBI)

This gene has 9 transcripts (splice variants), 307 orthologues and 53 paralogues. Low expression observed in reference dataset.

功能概要

预测启用跨膜肾上腺素受体活性。预计参与轴突导向;激酶活性的正调节;和跨膜受体蛋白酪氨酸激酶信号通路。位于核质中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EPHA6 基因产物(4)

mRNA Protein Name
NM_001080448.3 NP_001073917.2 ephrin type-A receptor 6 isoform a
NM_001278300.2 NP_001265229.1 ephrin type-A receptor 6 isoform c
NM_001278301.2 NP_001265230.1 ephrin type-A receptor 6 isoform d
NM_173655.4 NP_775926.1 ephrin type-A receptor 6 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
31483918 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

EPHA6 蛋白结构

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (128 - 301)

fn3

fn3: Fibronectin type III domain (427 - 518)

fn3

fn3: Fibronectin type III domain (549 - 621)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (643 - 722)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (726 - 807)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (838 - 1024)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (1059 - 1117)

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  • 1130 a.a.
蛋白主名 其他名称

ephrin type-A receptor 6

EPH homology kinase 2

EPHA6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EPHA6 Q9UF33 ACVR1 Homo sapiens Q04771
Anti Tag CoIP
31483918
种属内
EPHA6 Q9UF33 EPHA2 Homo sapiens P29317
Affinity Chrom
35384245
种属内
EPHA6 Q9UF33 EPHA2 Homo sapiens P29317
BioID
35384245
种属内
EPHA6 Q9UF33 EPHB4 Homo sapiens P54760
Anti Tag CoIP
35384245
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cefuroxime Allergy

Cephuroxime Allergy

Zinacef Allergy

Oculoauricular Syndrome

OCACS

Schorderet-Munier-Franceschetti Syndrome

Microphthalmia, Microcornea, Anterior Segment Dysgenesis, Cataract, Ocular Coloboma, Retinal Pigment Epithelium Abnormalities, Rod-Cone Dystrophy, And Anomalies Of The External Ear

Oculoauricular Syndrome, Schorderet Type

Oculo-Auricular Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus EPHA6 MGD MGI:108034
Felis catus EPHA6 VGNC VGNC:102693
Bos taurus EPHA6 VGNC VGNC:28536
Canis familiaris EPHA6 VGNC VGNC:58302
Rattus norvegicus EPHA6 RGD RGD:1304614
Macaca mulatta EPHA6 VGNC VGNC:84183
Others EPHA6 NCBI