2. Gene
  3. RGMB - repulsive guidance molecule BMP co-receptor b Gene

RGMB - repulsive guidance molecule BMP co-receptor b Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：排斥性引导分子 BMP 辅助受体 b

种属: Homo sapiens

同用名: DRAGON

基因 ID: 285704 | 基因类型: protein coding

关于 RGMB

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:98,768,632-98,796,494 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 10.1), skin (RPKM 10.1) and 24 other tissues.

功能概要

RGMB 是糖基磷脂酰肌醇 (GPI) 锚定的排斥性引导分子家族成员 (参见 RGMA，MIM 607362) ，有助于发育中神经系统的模式化 (Samad 等人，2005 [PubMed 15671031]) 。[OMIM 提供, 2009 年 4 月]

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]

RGMB 基因产物(5)

mRNA Protein Name
NM_001012761.3 NP_001012779.2 repulsive guidance molecule B isoform 2
NM_001366508.1 NP_001353437.1 repulsive guidance molecule B isoform 1 precursor
NM_001366509.1 NP_001353438.1 repulsive guidance molecule B isoform 2
NM_001366510.1 NP_001353439.1 repulsive guidance molecule B isoform 2
NM_001366511.1 NP_001353440.1 repulsive guidance molecule B isoform 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25938661 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RGMB 蛋白结构

RGM_N

RGM_N: Repulsive guidance molecule (RGM) N-terminus (54 - 221)

RGM_C

RGM_C: Repulsive guidance molecule (RGM) C-terminus (226 - 407)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 437 a.a.
蛋白主名 其他名称

repulsive guidance molecule B

DRG11-responsive axonal guidance and outgrowth of neurite

RGMB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
RGMB Q6NW40 Neo1 Mus musculus P97798
SAXS
25938661
种属间
RGMB Q6NW40 Neo1 Mus musculus P97798
GMS
25938661
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RGMB 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76573 RGMB Protein, Human (HEK293, His) Q6NW40/J3KNF6 (G46-N413) ≥95%

关联疾病

疾病名称 别名
Hemochromatosis Type 2

Juvenile Hemochromatosis

Juvenile Hereditary Hemochromatosis

Hfe2

Jhh

Hemochromatosis Juvenile

Iron Overload Disease Juvenile

Hemochromatosis, Juvenile

Hemochromatosis, Type 2

Hemochromatosis

Hemochromatosis, Type 1
Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11895 RGMB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RGMB RGD RGD:1595392
Macaca mulatta RGMB VGNC VGNC:76843
Felis catus RGMB VGNC VGNC:102308
Mus musculus RGMB MGD MGI:1916049
Bos taurus RGMB VGNC VGNC:55306
Others RGMB NCBI
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