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  2. GRK4 - G protein-coupled receptor kinase 4 Gene

GRK4 - G protein-coupled receptor kinase 4 Gene

中文名称:G 蛋白偶联受体激酶 4

种属: Homo sapiens

同用名: IT11; GPRK4; GRK4a; GPRK2L

基因 ID: 2868 | 基因类型: protein coding

关于 GRK4

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,963,571-3,040,760 (from NCBI)

This gene has 10 transcripts (splice variants), 187 orthologues and 7 paralogues. Biased expression in testis (RPKM 14.6) and brain (RPKM 0.7).

功能概要

该基因编码 Ser/Thr 蛋白激酶家族的鸟嘌呤核苷酸结合蛋白 (G 蛋白) 偶联受体激酶亚家族的成员。该蛋白磷酸化 G 蛋白偶联受体的活化形式,从而启动其失活。该基因与遗传性和获得性高血压有关。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供,2013 年 11 月]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GRK4 基因产物(5)

mRNA Protein Name
NM_001004056.2 NP_001004056.1 G protein-coupled receptor kinase 4 isoform beta
NM_001004057.2 NP_001004057.1 G protein-coupled receptor kinase 4 isoform gamma
NM_001350173.2 NP_001337102.1 G protein-coupled receptor kinase 4 isoform 5
NM_005307.3 NP_005298.2 G protein-coupled receptor kinase 4 isoform delta
NM_182982.3 NP_892027.2 G protein-coupled receptor kinase 4 isoform alpha
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32707033 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in receptor internalization IDA
IDA: 通过直接分析推断
20074556 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GRK4 蛋白结构

RGS

RGS: Regulator of G protein signaling domain (53 - 171)

Pkinase

Pkinase: Protein kinase domain (189 - 447)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 578 a.a.
蛋白主名 其他名称

G protein-coupled receptor kinase 4

G protein-coupled receptor kinase 2-like

GRK4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GRK4 P32298 GRK6 Homo sapiens P43250
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Hermansky-Pudlak Syndrome 3

HPS3

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Delta Storage Pool Disease

Hermansky-Pudlak Syndrome, Type 3

Platelet Storage Pool Deficiency

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus GRK4 MGD MGI:95801
Rattus norvegicus GRK4 RGD RGD:61858
Macaca mulatta GRK4 VGNC VGNC:73266
Canis familiaris GRK4 VGNC VGNC:41504
Bos taurus GRK4 VGNC VGNC:29655
Felis catus GRK4 VGNC VGNC:78506
Others GRK4 NCBI