2. Gene
  3. GRK6 - G protein-coupled receptor kinase 6 Gene

GRK6 - G protein-coupled receptor kinase 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体激酶 6

种属: Homo sapiens

同用名: GPRK6

基因 ID: 2870 | 基因类型: protein coding

关于 GRK6

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,425,523-177,442,891 (from NCBI)

This gene has 11 transcripts (splice variants), 209 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 27.2), lymph node (RPKM 19.5) and 23 other tissues.

功能概要

该基因编码 Ser/Thr 蛋白激酶家族的鸟嘌呤核苷酸结合蛋白 (G 蛋白) 偶联受体激酶亚家族的成员。该蛋白质磷酸化 G 蛋白偶联受体的活化形式，从而启动它们的失活。已经描述了该基因的几种编码不同亚型的转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GRK6 基因产物(4)

mRNA Protein Name
NM_001004105.3 NP_001004105.1 G protein-coupled receptor kinase 6 isoform C
NM_001004106.3 NP_001004106.1 G protein-coupled receptor kinase 6 isoform A
NM_001364164.2 NP_001351093.1 G protein-coupled receptor kinase 6 isoform D
NM_002082.4 NP_002073.2 G protein-coupled receptor kinase 6 isoform B
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-adrenergic receptor kinase activity IDA
IDA: 通过直接分析推断
20038610 GOA
enables beta-adrenergic receptor kinase activity IMP
IMP: 通过突变表型推断
20038610 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20729810 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GRK6 蛋白结构

RGS

RGS: Regulator of G protein signaling domain (53 - 170)

Pkinase

Pkinase: Protein kinase domain (187 - 448)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 576 a.a.
蛋白主名 其他名称

G protein-coupled receptor kinase 6

GRK6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GRK6 P43250 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
GRK6 P43250 GRK4 Homo sapiens P32298
Pull Down
32707033
种属间
GRK6 P43250 ROM1 Bos taurus P52205
Protein Kinase Assay
20729810
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GRK6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75799 GRK6 Protein, Human (sf9, His-GST) P43250-2 (M1-R589) ≥95%

GRK6 抗体

目录号 产品名 应用 反应物种
HY-P83207 GRK6 Antibody (YA2952) WB Human, Mouse

关联疾病

疾病名称 别名
Whim Syndrome 1

Whim Syndrome

Whims

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis

WHIMS1

Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1

Myelokathexis, Isolated

Wilm

Warts-Infections-Leukopenia-Myelokatexis Syndrome

Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-142812 GRK6-IN-1 99.64% 否
HY-142817 GRK6-IN-2 99.39% 否
HY-128311 GRK6-IN-3 Inhibitor / 否
HY-150021 GRK5-IN-3 Inhibitor / 否
HY-RS05817 GRK6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-159996 GRL093-22 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GRK6 VGNC VGNC:73268
Felis catus GRK6 VGNC VGNC:67449
Bos taurus GRK6 VGNC VGNC:29657
Mus musculus GRK6 MGD MGI:1347078
Rattus norvegicus GRK6 RGD RGD:61986
Canis familiaris GRK6 VGNC VGNC:41506
Others GRK6 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z